Evidence map›Paper›PMID 25864816›Full record

ArticleIranian biomedical journal2015

Improvement of tissue survival of skin flaps by 5α-reductase inhibitors: possible involvement of nitric oxide and inducible nitric oxide synthase.

Ali Asghar Karimi, Marjan Ajami, Yasin Asadi, Nahid Aboutaleb, Fazel Gorjipour, Roya Malekloo, Hamidreza Pazoki-Toroudi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian biomedical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ali Asghar KarimiDept. of Physiology and Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Marjan AjamiDept. of Food and Nutrition Policy and Planning Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Yasin AsadiPhysiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Nahid AboutalebPhysiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Fazel GorjipourDept. of Physiology and Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Roya MaleklooPhysiology Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Hamidreza Pazoki-ToroudiDept. of Physiology and Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRSemnan University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. In a previous study, we demonstrated the beneficial effects of two 5α-reductase inhibitors, azelaic acid and finasteride, on tissue survival in a rat model of skin flap grafting. In the current study, we investigated the involvement of nitric oxide and inducible nitric oxide synthase (iNOS) in graft survival mediated by these agents.

methodsA number of 42 male rats were randomly allocated into six groups: 1, normal saline topical application; 2, azelaic acid (100 mg/flap); 3, finasteride (1 mg/flap); 4, injection of L-NG-nitroarginine methyl ester (L-NAME) (i.p., 20 mg/kg); 5, L-NAME (20 mg/kg, i.p.) + azelaic acid (100 mg/flap, topical); 6, L-NAME (20 mg/kg, i.p.) + finasteride (1 mg/flap, topical). Tissue survival, level of nitric oxide, and iNOS expression in groups were measured.

resultsOur data revealed that azelaic acid and finasteride significantly increased the expression of iNOS protein and nitric oxide (NO) levels in graft tissue (P < 0.05). These increases in iNOS expression and NO level were associated with higher survival of the graft tissue.

conclusionIt appears that alterations of the NO metabolism are implicated in the azelaic acid- and finasteride-mediated survival of the skin flaps.

Indexed as

5-alpha Reductase InhibitorsAnimalsCholestenone 5 alpha-ReductaseDicarboxylic AcidsFinasterideGraft SurvivalMaleNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIPlastic Surgery ProceduresRandom AllocationRatsRats, Sprague-DawleySkinSkin Transplantation5-alpha Reductase Inhibitorsazelaic acidCholestenone 5 alpha-ReductaseDicarboxylic AcidsFinasterideNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IINOS2 protein, humanAzelaic acidFinasterideNitric oxide synthase Type IISurgical flaps

Identifiers

PMID25864816
PMCPMC4412922
OpenAlexW2101378181

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.