Evidence map›Paper›PMID 25864799›Full record

ArticleRespiratory physiology & neurobiology2015

Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats.

Chun-Chun Hsu, Reyno J Tapia, Lu-Yuan Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chun-Chun HsuDepartment of Physiology, University of Kentucky Medical Center, 800 Rose St., MS511A, Lexington, KY 40536-0298, USA.
Reyno J TapiaDepartment of Physiology, University of Kentucky Medical Center, 800 Rose St., MS511A, Lexington, KY 40536-0298, USA.
Lu-Yuan LeeDepartment of Physiology, University of Kentucky Medical Center, 800 Rose St., MS511A, Lexington, KY 40536-0298, USA. Electronic address: lylee@uky.edu.
University of Kentucky · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Role of TRPV1 in Airway Hypersensitivity Induced by InflammationR01HL096914 · NHLBI · UNIVERSITY OF KENTUCKY · PI LEE, LU-YUAN · 2009 to 2010
$703k
NCATS NIH HHS UL1TR0000117NCATS NIH HHS UL1 TR000117NHLBI NIH HHS HL-96914NHLBI NIH HHS R01 HL096914
6 · The paper itself

Abstract

This study was carried out to determine whether hyperventilation of humidified warm air (HWA) induced airway extravasation in ovalbumin (Ova)-sensitized rats. Our results showed: (1) After isocapnic hyperventilation with HWA for 2 min, tracheal temperature (Ttr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651% and 707%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats. (2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a pretreatment with either L-732138, a selective antagonist of neurokinin type 1 (NK-1) receptor, or formoterol, a selective agonist of β2 adrenoceptor. This study demonstrated that an increase in airway temperature induced protein extravasation in the major airways and lung tissue of sensitized rats, and an activation of the NK-1 receptor by tachykinins released from bronchopulmonary C-fiber nerve endings was primarily responsible.

Indexed as

Airway ResistanceAnalysis of VarianceAnimalsBenzamidesBronchoalveolar Lavage FluidBronchodilator AgentsEvans BlueFormoterol FumarateHot TemperatureMaleOvalbuminPiperidinesRatsRespiratory HypersensitivityTracheaTryptophan3,5-bis(trifluoromethyl)benzyl N-acetyltryptophanBenzamidesBronchodilator AgentsEvans BlueFormoterol FumarateOvalbuminPiperidinesSR 48968TryptophanAsthmaBronchoconstrictionC-fiberTachykininsVagus

Identifiers

PMID25864799
PMCPMC4437191
OpenAlexW1969357378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.