ArticleNeuron2015
Activity of defined mushroom body output neurons underlies learned olfactory behavior in Drosophila.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.
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181 citing papers in PubMed.
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- Aversive memory and extinction learning for noxious stimuli and aversive tastants in bumblebees.The Journal of experimental biology · 2026Article
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- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
- Octopamine signaling regulates the intracellular pattern of the presynaptic active zone scaffold within Drosophila mushroom body neurons.PLoS biology · 2025Article
- A distinct neural ensemble to integrate contradictory information and form long-term memory inScience advances · 2025Article
- A pair of dopaminergic neurons DAN-c1 mediateeLife · 2025Article
- A temporally restricted function of the dopamine receptor Dop1R2 during memory formation.eLife · 2025Article
- In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies.Journal of visualized experiments : JoVE · 2025Article
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A biological model of nonlinear dimensionality reduction.Science advances · 2025Article
- Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons.eLife · 2025Article
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- The exponential distance rule-based network model predicts topology and reveals functionally relevant properties of theNetwork neuroscience (Cambridge, Mass.) · 2025Article
121 more citing papers are in PubMed but not listed here.
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Abstract
During olfactory learning in fruit flies, dopaminergic neurons assign value to odor representations in the mushroom body Kenyon cells. Here we identify a class of downstream glutamatergic mushroom body output neurons (MBONs) called M4/6, or MBON-β2β'2a, MBON-β'2mp, and MBON-γ5β'2a, whose dendritic fields overlap with dopaminergic neuron projections in the tips of the β, β', and γ lobes. This anatomy and their odor tuning suggests that M4/6 neurons pool odor-driven Kenyon cell synaptic outputs. Like that of mushroom body neurons, M4/6 output is required for expression of appetitive and aversive memory performance. Moreover, appetitive and aversive olfactory conditioning bidirectionally alters the relative odor-drive of M4β' neurons (MBON-β'2mp). Direct block of M4/6 neurons in naive flies mimics appetitive conditioning, being sufficient to convert odor-driven avoidance into approach, while optogenetically activating these neurons induces avoidance behavior. We therefore propose that drive to the M4/6 neurons reflects odor-directed behavioral choice.
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