ArticleThe Journal of physiology2016
Sympathetic neural activation does not mediate heart rate variability during repeated brief umbilical cord occlusions in near-term fetal sheep.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Fetal autonomic responses inferred from heart rate variability during recurrent decelerations without acidosis-An observational study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Observational
- Antenatal Corticosteroids in Early and Late Fetal Growth Restriction.Journal of clinical medicine · 2025Review
- Atrioventricular conduction abnormalities are associated with poor outcome following intermittent umbilical cord occlusions in fetal sheep.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Circadian patterns of heart rate variability in fetal sheep after hypoxia-ischaemia: A biomarker of evolving brain injury.The Journal of physiology · 2024Article
- Increased variability of fetal heart rate during labour: a review of preclinical and clinical studies.BJOG : an international journal of obstetrics and gynaecology · 2022Review
- Associations between fetal heart rate variability and umbilical cord occlusions-induced neural injury: An experimental study in a fetal sheep model.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Heart rate markers for prediction of fetal acidosis in an experimental study on fetal sheep.Scientific reports · 2022Article
- Fetal respiratory movements improve reliability of heart rate variability and suggest a coupling between fetal respiratory arrhythmia and vagal activity.Physiological reports · 2022Article
- Fetal heart rate variability analysis for neonatal acidosis prediction.Journal of clinical monitoring and computing · 2021Article
- Reply to the "Letter to the Editor: measurement of fetal parasympathetic activity during labor: a new pathway for evaluation of fetal well-being?"American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Article
- Plasma vasopressin levels are closely associated with fetal hypotension and neuronal injury after hypoxia-ischemia in near-term fetal sheep.Pediatric research · 2020Article
- Marked variability in intrapartum electronic fetal heart rate patterns: association with neonatal morbidity and abnormal arterial cord gas.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Maternal and fetal cardiometabolic recovery following ultrasound-guided high-intensity focused ultrasound placental vascular occlusion.Journal of the Royal Society, Interface · 2019Article
- Evolving changes in fetal heart rate variability and brain injury after hypoxia-ischaemia in preterm fetal sheep.The Journal of physiology · 2018Article
- The peripheral chemoreflex: indefatigable guardian of fetal physiological adaptation to labour.The Journal of physiology · 2018Review
- Altered autonomic control of heart rate variability in the chronically hypoxic fetus.The Journal of physiology · 2018Article
- A prospective cohort study of fetal heart rate monitoring: deceleration area is predictive of fetal acidemia.American journal of obstetrics and gynecology · 2018Article
- An investigation of fetal behavioural states during maternal sleep in healthy late gestation pregnancy: an observational study.The Journal of physiology · 2017Observational
- Reply from Christopher A. Lear, Robert Galinsky, Guido Wassink, Kyohei Yamaguchi, Joanne O. Davidson, Jenny A. Westgate, Laura Bennet and Alistair J. Gunn.The Journal of physiology · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in fetal heart rate variability (FHRV) and ST segment elevation (measured as the T/QRS ratio) are used to evaluate fetal adaptation to labour. The sympathetic nervous system (SNS) is an important contributor to FHRV under healthy normoxic conditions, and is critical for rapid support of blood pressure during brief labour-like asphyxia. However, although it has been assumed that SNS activity contributes to FHRV during labour; this has never been tested, and it is unclear whether the SNS contributes to the rapid increase in T/QRS ratio during brief asphyxia. Thirteen chronically instrumented fetal sheep at 0.85 of gestation received either chemical sympathectomy with 6-hydroxydopamine (6-OHDA; n = 6) or sham treatment (control; n = 7), followed 4-5 days later by 2 min episodes of complete umbilical cord occlusion repeated every 5 min for up to 4 h, or until mean arterial blood pressure fell to <20 mmHg for two successive occlusions. FHRV was decreased before occlusions in the 6-OHDA group (P < 0.05) and 2-4.5 h during recovery after occlusions (P < 0.05) compared to the control group. During each occlusion there was a rapid increase in T/QRS ratio. Between successive occlusions the T/QRS ratio rapidly returned to baseline, and FHRV increased above baseline in both groups (P < 0.05), with no significant effect of sympathectomy on FHRV or T/QRS ratio. In conclusion, these data show that SNS activity does not mediate the increase in FHRV between repeated episodes of brief umbilical cord occlusion or the transient increase in T/QRS ratio during occlusions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.