ReviewNeurosciences (Riyadh, Saudi Arabia)2015
Update on neuropathic pain treatment for trigeminal neuralgia. The pharmacological and surgical options.
Review in Neurosciences (Riyadh, Saudi Arabia), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06129071 (Analgesic Effect Evaluation of Ultrasound Guided Maxillary Nerve Block in Trigeminal Neuralgia), which is not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analgesic Effect Evaluation of Ultrasound Guided Maxillary Nerve Block in Trigeminal Neuralgia
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 181 citations in OpenAlex.
- Invasive and Non-Invasive Electrical Neuromodulation in Trigeminal Nerve Neuralgia: A Systematic Review and Meta-Analysis.Current neuropharmacology · 2021Pooled it
- Triple Puncture for Primary Trigeminal Neuralgia: A Randomized Clinical Trial.Current medical science · 2019Trial
- Treatment of trigeminal neuralgia: single-fraction LINAC-based radiosurgery option, mono-institutional experience with long follow-up.La Radiologia medica · 2026Article
- Targeting neurovascular conflict in atypical vagal-glossopharyngeal neuralgia: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Neurovascular Compression Syndromes of Cranial Nerves: A Multidisciplinary Guide to Management.Brain sciences · 2026Review
- Pivotal Factors for Minimizing the Risks of Therapeutic Failure in Trigeminal Neuralgia and Hemifacial Spasm.Current pain and headache reports · 2026Review
- Jawbone Cavitations: Current Understanding and Conceptual Introduction of Covered Socket Residuum (CSR).Bioengineering (Basel, Switzerland) · 2026Review
- Decoding orofacial pain: a translational review of mechanisms and novel therapies.The journal of headache and pain · 2025Review
- Article
- Case series of CT-fusion and real-time US-guidance in percutaneous RF thermocoagulation for trigeminal rhizotomy.Pain management · 2025Article
- Trigeminal Neuralgia Treatment via Piezosurgical Enlargement of the Mental Foramen.Life (Basel, Switzerland) · 2025Article
- Navigating precision: Anatomical insights into the efficacy of masks versus stereotactic frames in icon gamma knife treatment for trigeminal neuralgia.Surgical neurology international · 2025Article
- Effectiveness of Radiofrequency in Treating Pain Associated With Trigeminal Neuralgia in Oncologic Patients.Cureus · 2025Article
- Efficacy of single vs. multiple botulinum toxin type A injections for trigeminal neuralgia.Frontiers in neurology · 2025Article
- Retreatment predictors after percutaneous balloon gangliolysis for trigeminal neuralgia.Neurosurgical review · 2024Article
- Chiari malformation and its influence on trigeminal neuralgia: a systematic review.Annals of medicine and surgery (2012) · 2024Review
- Exploring Carbamazepine Polymorph Crystal Growth in Water by Enhanced Sampling Simulations.ACS omega · 2024Article
- Meta-analysis and sequential analysis of acupuncture compared to carbamazepine in the treatment of trigeminal neuralgia.World journal of clinical cases · 2024Article
- Modern Approaches to the Treatment of Acute Facial Pain.Current pain and headache reports · 2024Review
- Outcomes of Different Surgical Interventions for Treating Trigeminal Neuralgia: A Review.Cureus · 2024Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trigeminal neuralgia is a syndrome of unilateral, paroxysmal, stabbing facial pain, originating from the trigeminal nerve. Careful history of typical symptoms is crucial for diagnosis. Most cases are caused by vascular compression of the trigeminal root adjacent to the pons leading to focal demyelination and ephaptic axonal transmission. Brain imaging is required to exclude secondary causes. Many medical and surgical treatments are available. Most patients respond well to pharmacotherapy; carbamazepine and oxcarbazepine are first line therapy, while lamotrigine and baclofen are considered second line treatments. Other drugs such as topiramate, levetiracetam, gabapentin, pregabalin, and botulinum toxin-A are alternative treatments. Surgical options are available if medications are no longer effective or tolerated. Microvascular decompression, gamma knife radiosurgery, and percutaneous rhizotomies are most promising surgical alternatives. This paper reviews the medical and surgical therapeutic options for the treatment of trigeminal neuralgia, based on available evidence and guidelines.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.