Evidence map›Paper›PMID 25863973›Full record

ArticleJACC. Heart failure2015

Race and Vitamin D Binding Protein Gene Polymorphisms Modify the Association of 25-Hydroxyvitamin D and Incident Heart Failure: The ARIC (Atherosclerosis Risk in Communities) Study.

Pamela L Lutsey, Erin D Michos, Jeffrey R Misialek, James S Pankow, Laura Loehr, Elizabeth Selvin, Jared P Reis, Myron Gross, John H Eckfeldt, Aaron R Folsom

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Serum 25-hydroxyvitamin D and the incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2016
    Pooled it
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  10. Unravelling the Contribution of the rs7041 and rs4588 Polymorphisms of theInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Pamela L LutseyDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota. Electronic address: lutsey@umn.edu.
Erin D MichosDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland.
Jeffrey R MisialekDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
Laura LoehrDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
Elizabeth SelvinDepartments of Epidemiology and Medicine, Johns Hopkins University, Baltimore, Maryland.
Jared P ReisDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Myron GrossLab Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
John H EckfeldtLab Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
Aaron R FolsomDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · USJohns Hopkins University · USNational Heart Lung and Blood Institute · USUniversity of North Carolina at Chapel Hill · US

Funding

Diabetes and Prediabetes in Older Adults in ARICR01DK089174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2011 to 2020
$6.4M
Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC CohortR01HL103706 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2011 to 2014
$2.3M
BLOOD COAGULATION &FIBRINOLYSISR01HL065226 · NHLBI · SCRIPPS RESEARCH INSTITUTE · PI MACKMAN, NIGEL · 2000 to 2004
$1.8M
Vitamin D, cerebrovascular risk, and neurocognitive decline: ARIC Brain MRI StudyR01NS072243 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MICHOS, ERIN D · 2011 to 2014
$1.4M
FIELD CENTER FOR CCSPN01HC055019 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1985 to 2000
$748k
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC065226NHLBI NIH HHS R01 HL103706NIDDK NIH HHS R01 DK089174NINDS NIH HHS R01 NS072243
6 · The paper itself

Abstract

objectivesThis study sought to determine if low serum 25-hydroxyvitamin D (25[OH]D) is associated with incident heart failure (HF) and if the association is: 1) partly mediated by traditional cardiovascular risk factors; 2) stronger among whites than blacks; and 3) stronger among those genetically predisposed to having high levels of vitamin D binding protein (DBP).

backgroundSuboptimal 25(OH)D is a potential cardiovascular risk factor.

methodsA total of 12,215 ARIC (Atherosclerosis Risk in Communities) study participants free of HF at baseline (1990 to 1992; median age, 56; 24% black) were followed through 2010. Total serum 25(OH)D was measured at baseline using liquid chromatography-mass spectrometry. Incident HF events were identified by a hospital discharge code of ICD9-428 and parallel International Classification of Diseases codes for HF deaths.

resultsDuring 21 years of follow-up, 1,799 incident HF events accrued. The association between 25(OH)D and HF varied by race (p-interaction = 0.02). Among whites, risk was 2-fold higher for those in the lowest (≤17 ng/ml) versus highest (≥31 ng/ml) quintile of 25(OH)D. The association was attenuated but remained significant with covariate adjustment. In blacks there was no overall association. In both races, those with low 25(OH)D and the rs7041 G allele, which predisposes to high DBP, were at greater risk (p-interaction = 0.01).

conclusionsLow serum 25(OH)D was independently associated with incident HF among whites, but not among blacks. However, in both races, low 25(OH)D was associated with HF risk among those genetically predisposed to high DBP. These findings provide novel insight into metabolic differences that may underlie racial variation in the association between 25(OH)D and cardiovascular risk.

Indexed as

Polymorphism, GeneticRacial GroupsAtherosclerosisFemaleHeart FailureHumansIncidenceMaleMiddle AgedRisk AssessmentRisk FactorsRNAUnited StatesVitamin DVitamin D-Binding Protein25-hydroxyvitamin DRNAVitamin DVitamin D-Binding ProteinARICheart failureracevitamin Dvitamin D binding protein

Identifiers

PMID25863973
PMCPMC4426050
OpenAlexW588122437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.