ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2015
Fluorescence-guided resection with 5-aminolevulinic acid of meningeal sarcoma in a child.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- 5-Aminolevulinic acid (5-ALA) in paediatric brain tumour surgery-a systematic review and exploration of fluorophore alternatives.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review.Journal of neuro-oncology · 2019Pooled it
- Review
- Utility and Safety of 5-ALA Guided Surgery in Pediatric Brain Tumors: A Systematic Review.Cancers · 2024Review
- Fluorescence Diagnosis in Neurooncology: Retrospective Analysis of 653 Cases.Frontiers in oncology · 2019Article
- 5ALA in pediatric brain tumors is not routinely beneficial.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Undifferentiated meningeal sarcoma of childhood presenting as hard mass adhered to major intracranial vessels.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe usefulness of fluorescence-guided resection with 5-aminolevulinic acid for malignant brain gliomas was demonstrated by Stummer. However, there are several articles in the literature showing the usefulness of the technique for other types of tumors, including benign tumors, such as ependymomas or meningiomas. Meningeal sarcomas are rare, highly aggressive malignant tumors, predominately affecting the pediatric population and have a poor prognosis in spite of treatment. Surgical treatment thereof should consist of the most complete resection possible.
methodsIn this article, we present the case of a seven-year-old boy who received surgical treatment for a left frontal tumor after oral administration of 5-aminolevulinic acid (5-ALA); the definitive histological diagnosis of which was meningeal sarcoma. The technique was useful for achieving a complete resection, as the lesion emitted intense fluorescence, and after resection of the lesion with the usual technique, intraoperative fluorescent spots were observed in the resection bed that were also tumor. Imaging tests performed 5 years after surgery ruled out recurrence of the tumor.
conclusionTo our knowledge, this is the first case published in the literature of meningeal sarcoma in a child in which intraoperative fluorescence with 5-ALA was used to achieve a complete resection.
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