ArticleCerebellum (London, England)2015
Maternal immune activation produces cerebellar hyperplasia and alterations in motor and social behaviors in male and female mice.
Article in Cerebellum (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Maternal systemic autoimmune rheumatic diseases and childhood mental disorders: a nationwide cohort study.Lupus science & medicine · 2026Article
- A "personality test" for rats reveals subtle but distinct effects of sex and early life inflammation on brain and behavior.Behavioral neuroscience · 2026Article
- Autism Spectrum Disorder: The Cerebellum, Genes, and Pathways.Neurology international · 2025Review
- Maternal prenatal immune activation associated with brain tissue microstructure and metabolite concentrations in newborn infants.Brain, behavior, and immunity · 2024Article
- Understanding the phenotypic variability in Niemann-Pick disease type C (NPC): a need for precision medicine.NPJ genomic medicine · 2023Review
- Maternal immune activation affects socio-communicative behavior in adult rats.Scientific reports · 2023Article
- Microglia-dependent remodeling of neuronal circuits.Journal of neurochemistry · 2022Review
- Effects of maternal immune activation in porcine transcript isoforms of neuropeptide and receptor genes.Journal of integrative neuroscience · 2021Article
- The Effect of Maternal Immune Activation on Social Play-Induced Ultrasonic Vocalization in Rats.Brain sciences · 2021Article
- Maternal immune activation modifies the course of Niemann-pick disease, type C1 in a gender specific manner.Molecular genetics and metabolism · 2020Article
- Long-Lasting Impact of Maternal Immune Activation and Interaction With a Second Immune Challenge on Pig Behavior.Frontiers in veterinary science · 2020Article
- Lasting and Sex-Dependent Impact of Maternal Immune Activation on Molecular Pathways of the Amygdala.Frontiers in neuroscience · 2020Article
- Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology.Brain, behavior, and immunity · 2019Review
- Brain changes in a maternal immune activation model of neurodevelopmental brain disorders.Progress in neurobiology · 2019Review
- Inflammation: A Proposed Intermediary Between Maternal Stress and Offspring Neuropsychiatric Risk.Biological psychiatry · 2019Review
- Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.Frontiers in microbiology · 2018Article
- Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia.Frontiers in molecular neuroscience · 2018Article
- Maternal Immune Activation and Autism Spectrum Disorder: From Rodents to Nonhuman and Human Primates.Biological psychiatry · 2017Review
- The immune system as a novel regulator of sex differences in brain and behavioral development.Journal of neuroscience research · 2017Review
- Editorial on the honorary cerebellum issue for the retirement of Enrico Mugnaini.Cerebellum (London, England) · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
There have been suggestions that maternal immune activation is associated with alterations in motor behavior in offspring. To explore this further, we treated pregnant mice with polyinosinic:polycytidylic acid (poly(I:C)), a viral mimetic that activates the innate immune system, or saline on embryonic days 13-15. At postnatal day (P) 18, offspring cerebella were collected from perfused brains and immunostained as whole-mounts for zebrin II. Measurements of zebrin II+/- stripes in both sexes indicated that prenatal poly(I:C)-exposed offspring had significantly wider stripes; this difference was also seen in similarly treated offspring in adulthood (~P120). When sagittal sections of the cerebellum were immunostained for calbindin and Purkinje cell numbers were counted, we observed greater numbers of Purkinje cells in poly(I:C) offspring at both P18 and ~ P120. In adolescence (~P40), both male and female prenatal poly(I:C)-exposed offspring exhibited poorer performance on the rotarod and ladder rung tests; deficits in performance on the latter test persisted into adulthood. Offspring of both sexes from poly(I:C) dams also exhibited impaired social interaction in adolescence, but this difference was no longer apparent in adulthood. Our results suggest that maternal immune exposure at a critical time of cerebellum development can enhance neuronal survival or impair normal programmed cell death of Purkinje cells, with lasting consequences on cerebellar morphology and a variety of motor and non-motor behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.