ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2015
The effect of nifedipine on retinal venous pressure of glaucoma patients with the Flammer-Syndrome.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The lowering of the intraocular pressure and the retinal venous pressure by cyclophotocoagulation.BMC ophthalmology · 2026Article
- [Glaucoma Patient with Suspected Flammer Syndrome: Diagnostic Procedures and Therapeutic Implications].Klinische Monatsblatter fur Augenheilkunde · 2024Review
- Peripapillary Oxygenation and Retinal Vascular Responsiveness to Flicker Light in Primary Open Angle Glaucoma.Metabolites · 2022Article
- Treatment of Glaucoma Patients with Flammer Syndrome.Journal of clinical medicine · 2021Review
- Retinal venous pressure is decreased after anti-VEGF therapy in patients with retinal vein occlusion-related macular edema.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- [Vasculat treatment concepts in glaucoma patients].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Review
- Risk Factors Associated with Structural Progression in Normal-Tension Glaucoma: Intraocular Pressure, Systemic Blood Pressure, and Myopia.Investigative ophthalmology & visual science · 2020Article
- In glaucoma patients, low blood pressure is accompanied by vascular dysregulation.The EPMA journal · 2018Article
- Retinal venous pressure measurements in patients with Flammer syndrome and metabolic syndrome.The EPMA journal · 2017Article
- The potential relationship between Flammer and Sjögren syndromes: the chime of dysfunction.The EPMA journal · 2017Review
- Acupuncture benefits for Flammer syndrome in individuals with inherited diseases of the retina.The EPMA journal · 2017Article
- Nutritional recommendations for individuals with Flammer syndrome.The EPMA journal · 2017Review
- The discovery of the Flammer syndrome: a historical and personal perspective.The EPMA journal · 2017Review
- Mystery of Retinal Vein Occlusion: Vasoactivity of the Vein and Possible Involvement of Endothelin-1.BioMed research international · 2017Review
- Suppressed endothelin-1 by anti-VEGF therapy is important for patients with BRVO-related macular edema to improve their vision.The EPMA journal · 2016Article
- Retinal venous pressure: the role of endothelin.The EPMA journal · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose was to measure the retinal venous pressure (RVP) in both eyes of primary open-angle glaucoma (POAG) patients before and 3 weeks after treatment with low-dosed Nifedipine.
methodsThis retrospective study included 20 POAG patients who were treated with Nifedipine (5 mg daily) and 20 untreated control POAG patients. In both the treated and untreated control group, a distinction was made between those patients who had the Flammer-Syndrome (FS) and those who did not. The RVP was measured in all patients bilaterally at baseline and 3 weeks later by means of contact lens ophthalmodynamometry and the RVP measurements of the treated POAG patients were compared to the RVPs of the untreated POAG controls. Ophthalmodynamometry is done by applying an increasing force on the eye via a contact lens. The minimum force required to induce a venous pulsation is called the ophthalmodynamometric force (ODF). The RVP is defined and calculated as the sum of ODF and intraocular pressure (IOP) [RVP = ODF + IOP].
resultsThe RVP decreased significantly after 3 weeks in both eyes of patients treated with low-dosed Nifedipine compared to the untreated group (mean decrease of 12.5 mmHg (SD 12.5), P < 0.001). A larger response to therapy was found in patients with the FS compared to patients lacking the FS (mean decrease of 16.07 vs. 7.28 mmHg, confidence Interval (CI): 5.2 to 9.3 vs. 12.3 to 19.7; P < 0.001). No significant differences were accounted for in the IOP's of the patients after treatment. In the untreated control group, no significant differences were accounted for either in the RVP or the IOP after 3 weeks.
conclusionsTreatment with low-dosed Nifedipine decreases RVP in both eyes of glaucoma patients, particularly in those with the Flammer-Syndrome. This effect may be due to the partial inhibition of Endothelin-1 (ET-1) by Nifedipine.
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