Evidence map›Paper›PMID 25863217›Full record

ArticleGastroenterology2015

Loss of Interstitial Cells of Cajal and Patterns of Gastric Dysrhythmia in Patients With Chronic Unexplained Nausea and Vomiting.

Timothy R Angeli, Leo K Cheng, Peng Du, Tim Hsu-Han Wang, Cheryl E Bernard, Maria-Giuliana Vannucchi, Maria Simonetta Faussone-Pellegrini, Christopher Lahr, Ryash Vather, John A Windsor and 3 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05789511 (High Resolution Electrogastrography), which is not on this map. Cited by 111 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 7 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05789511 unknown statusnot on this mapstarted 2022, after this paper: background citation

High Resolution Electrogastrography (HR-EGG) Assessment in Medically Refractory Gastroparesis

TypeobservationalSponsorUniversity of VirginiaRan2022 to 2025Enrolled40ConditionsGastroparesis, Lung Transplant, ComplicationsArmsHigh Resolution Electrogastography
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 7 syntheses or guidelines pooled it, 239 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2021
    Pooled it
  8. Trial
  9. Trial
  10. Review
  11. Gastric slow-wave morphology in health and disease.Digestive diseases and sciences · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Feature tracking-based motility analysis of excised intestinal tissue using video recordings.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Timothy R AngeliAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Leo K ChengAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; Department of Surgery, Vanderbilt University, Nashville, Tennessee.
Peng DuAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Tim Hsu-Han WangDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Cheryl E BernardDivision of Gastroenterology and Hepatology, Enteric Neurosciences Program, Mayo Clinic, Rochester, Minnesota.
Maria-Giuliana VannucchiHistology and Embryology Research Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Maria Simonetta Faussone-PellegriniHistology and Embryology Research Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Christopher LahrDepartment of Surgery, Mississippi Medical Center, Jackson, Mississippi.
Ryash VatherDepartment of Surgery, University of Auckland, Auckland, New Zealand.
John A WindsorDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Gianrico FarrugiaDivision of Gastroenterology and Hepatology, Enteric Neurosciences Program, Mayo Clinic, Rochester, Minnesota.
Thomas L AbellDepartment of Gastroenterology, University of Louisville, Louisville, Kentucky.
Gregory O'GradyAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; Department of Surgery, University of Auckland, Auckland, New Zealand. Electronic address: greg.ogrady@auckland.ac.nz.
University of Auckland · NZMayo Clinic · USUniversity of Florence · ITUniversity of Louisville · USUniversity of Mississippi Medical Center · USVanderbilt University · US

Funding

Gastroparesis Consortium Continuation-Data Coordinating CenterU01DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2006 to 2015
$17.4M
PGpR2 Year 4 Supplement for the Scientific Data Research Center (SDRC) of the GpCRC 4U24DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI David M Shade · 2017 to 2026
$11.7M
CALCIUM DYNAMICS IN INTERSTITIAL CELLS OF CAJALR01DK057061 · NIDDK · MAYO CLINIC ROCHESTER · PI GIANRICO FARRUGIA, Tamas Ordog · 2000 to 2026
$8.2M
U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis ConsortiumU01DK074007 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Thomas Lyman Abell · 2006 to 2026
$7.0M
Molecular Approaches to Pathogenesis/Therapy in GastropaU01DK073983 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PANKAJ J PASRICHA · 2006 to 2026
$6.8M
The GpCRC Pediatric Gastroparesis Registry 2 (PGpR2): Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants with Symptoms of GastU01DK074035 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Irene Sarosiek · 2008 to 2026
$6.7M
Realistic models of gastrointestinal bioelectromagnetismR01DK064775 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHENG, LEO · 2004 to 2014
$2.6M
NIDDK NIH HHS DK57061NIDDK NIH HHS DK73983NIDDK NIH HHS DK74008NIDDK NIH HHS R01 DK057061NIDDK NIH HHS R01 DK064775NIDDK NIH HHS R01 DK64775NIDDK NIH HHS U01 DK073983NIDDK NIH HHS U01 DK074007NIDDK NIH HHS U01 DK074008NIDDK NIH HHS U01 DK074035NIDDK NIH HHS U24 DK074008
6 · The paper itself

Abstract

BACKGROUND &

aimsChronic unexplained nausea and vomiting (CUNV) is a debilitating disease of unknown cause. Symptoms of CUNV substantially overlap with those of gastroparesis, therefore the diseases may share pathophysiologic features. We investigated this hypothesis by quantifying densities of interstitial cells of Cajal (ICCs) and mapping slow-wave abnormalities in patients with CUNV vs controls.

methodsClinical data and gastric biopsy specimens were collected from 9 consecutive patients with at least 6 months of continuous symptoms of CUNV but normal gastric emptying who were treated at the University of Mississippi Medical Center, and from 9 controls (individuals free of gastrointestinal disease or diabetes). ICCs were counted and ultrastructural analyses were performed on tissue samples. Slow-wave propagation profiles were defined by high-resolution electrical mapping (256 electrodes; 36 cm(2)). Results from patients with CUNV were compared with those of controls as well as patients with gastroparesis who were studied previously by identical methods.

resultsPatients with CUNV had fewer ICCs than controls (mean, 3.5 vs 5.6 bodies/field, respectively; P < .05), with mild ultrastructural abnormalities in the remaining ICCs. Slow-wave dysrhythmias were identified in all 9 subjects with CUNV vs only 1 of 9 controls. Dysrhythmias included abnormalities of initiation (stable ectopic pacemakers, unstable focal activities) and conduction (retrograde propagation, wavefront collisions, conduction blocks, and re-entry), operating across bradygastric, normal (range, 2.4-3.7 cycles/min), and tachygastric frequencies; dysrhythmias showed velocity anisotropy (mean, 3.3 mm/s longitudinal vs 7.6 mm/s circumferential; P < .01). ICCs were less depleted in patients with CUNV than in those with gastroparesis (mean, 3.5 vs 2.3 bodies/field, respectively; P < .05), but slow-wave dysrhythmias were similar between groups.

conclusionsThis study defined cellular and bioelectrical abnormalities in patients with CUNV, including the identification of slow-wave re-entry. Pathophysiologic features of CUNV were observed to be similar to those of gastroparesis, indicating that they could be spectra of the same disorder. These findings offer new insights into the pathogenesis of CUNV and may help to inform future treatments.

Indexed as

ElectromyographyGastrointestinal MotilityInterstitial Cells of CajalAdultAgedCase-Control StudiesElectrodiagnosisFemaleGastrointestinal DiseasesGastroparesisHumansMaleMiddle AgedNauseaVomitingYoung AdultGastroparesisHigh-Resolution MappingICCSlow-Wave

Identifiers

PMID25863217
PMCPMC4617790
OpenAlexW2160829471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.