ArticleEnvironmental research2015
Association of blood lead levels with urinary F₂-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children.
Article in Environmental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Relation Between Low-Level Lead Exposure and Oxidative Stress: a Review of the Epidemiological Evidence in Children and Non-Occupationally Exposed Adults.Current environmental health reports · 2016Pooled it
- Article
- Temperature stability of urinary FPractical laboratory medicine · 2024Article
- Predicting blood lead in Uruguayan children: Individual- vs neighborhood-level ensemble learners.PLOS global public health · 2024Article
- Dietary patterns and cognitive achievement among school children in socio-cultural context, a case of Montevideo, Uruguay.European journal of nutrition · 2023Article
- Reducing the complexity of high-dimensional environmental data: An analytical framework using LASSO with considerations of confounding for statistical inference.International journal of hygiene and environmental health · 2023Article
- Pyrethroid and Chlorpyrifos Pesticide Exposure, General Intellectual Abilities, and Executive Functions of School Children from Montevideo, Uruguay.International journal of environmental research and public health · 2023Article
- Genotoxic Biomonitoring in Children Living near the El Fraile Mine Tailings in Northern Guerrero State, Mexico.Toxics · 2022Article
- Article
- Contribution of household drinking water intake to arsenic and lead exposure among Uruguayan schoolchildren.Chemosphere · 2022Article
- A mixed methods study examining neighborhood disadvantage and childhood behavior problems in Montevideo, Uruguay.International journal of hygiene and environmental health · 2021Article
- Catching flame retardants and pesticides in silicone wristbands: Evidence of exposure to current and legacy pollutants in Uruguayan children.The Science of the total environment · 2020Article
- Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure.The Journal of nutrition · 2020Article
- Persistent Effects on Cardiorespiratory and Nervous Systems Induced by Long-Term Lead Exposure: Results from a Longitudinal Study.Neurotoxicity research · 2020Article
- Blood Lead Levels in Occupationally Exposed Workers Involved in Battery Factories of Delhi-NCR Region: Effect on Vitamin D and Calcium Metabolism.Indian journal of clinical biochemistry : IJCB · 2020Article
- Low level arsenic exposure, B-vitamins, and achievement among Uruguayan school children.International journal of hygiene and environmental health · 2020Article
- Latent subgroups of cognitive performance in lead- and manganese-exposed Uruguayan children: Examining behavioral signatures.Neurotoxicology · 2019Article
- Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values.Frontiers in molecular biosciences · 2019Review
- Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children.Environmental research · 2018Article
- Chronic lead exposure induces cochlear oxidative stress and potentiates noise-induced hearing loss.Toxicology letters · 2018Article
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
Oxidative stress (OS) is a potential molecular mechanism for lead-induced toxicities, yet, we have limited understanding of the relation between low-level lead (Pb) exposure and OS, especially in children. This cross-sectional study examines the association between blood lead level (BLL) and two OS markers-urinary F2-8α isoprostane or isoprostane (a marker of lipid peroxidation) and 8-hydroxy-2-deoxy-Guanosine or 8-OH-dG (a marker of DNA damage) in 211 children, aged 5-8 years, from Montevideo, Uruguay. The role of dietary intakes of vitamin C and zinc in modifying the relation between BLL and OS was also examined. The mean (SD) BLL of the study children was 4.7 (2.2) µg/dL, with 30.2% children having BLL ≥5 µg/dL, the current reference level set by the US Centre for Disease Control for identifying, monitoring and management of children with elevated BLL. In covariate-adjusted analysis, there was a weak positive association between BLL and urinary isoprostane (adjusted for specific gravity) [β=0.09, p<0.1]. No association was found between children's BLL and urinary 8-OH-dG. Interactions between dietary intakes of vitamin C or zinc and BLL on OS biomarkers were not consistent. However, when BLL and vitamin C or BLL and zinc were modeled together, BLL was independently associated with isoprostane concentration [β=0.10, p<0.05] but vitamin C or zinc intake was not. These findings suggest that there may be a potential adverse effect of BLL on OS in children with low-level Pb exposure. There is a need to study the effects of Pb on other OS measures, as well as the role of OS in mediating low-level Pb toxicity on functional outcomes.
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