ArticleBiophysical journal2015
Mathematical modeling and validation of glucose compensation of the neurospora circadian clock.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 35 citations in OpenAlex.
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Transcriptional rewiring of an evolutionarily conserved circadian clock.The EMBO journal · 2024Article
- Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis.Results and problems in cell differentiation · 2024Review
- Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability.PLoS biology · 2023Article
- Data-driven modelling captures dynamics of the circadian clock of Neurospora crassa.PLoS computational biology · 2022Article
- Restoring circadian gene profiles in clock networks using synthetic feedback control.NPJ systems biology and applications · 2022Article
- Principles underlying the complex dynamics of temperature entrainment by a circadian clock.iScience · 2021Article
- Mechanism for the Generation of Robust Circadian Oscillations through Ultransensitivity and Differential Binding Affinity.The journal of physical chemistry. B · 2021Article
- Universally valid reduction of multiscale stochastic biochemical systems using simple non-elementary propensities.PLoS computational biology · 2021Article
- Circadian rhythm shows potential for mRNA efficiency and self-organized division of labor in multinucleate cells.PLoS computational biology · 2021Article
- A systems biology approach to discovering pathway signaling dysregulation in metastasis.Cancer metastasis reviews · 2020Review
- Bayesian modeling reveals metabolite-dependent ultrasensitivity in the cyanobacterial circadian clock.Molecular systems biology · 2020Article
- An Inactivation Switch Enables Rhythms in aInternational journal of molecular sciences · 2019Article
- Circadian clock regulation of the glycogen synthase (Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Modeling Reveals a Key Mechanism for Light-Dependent Phase Shifts of Neurospora Circadian Rhythms.Biophysical journal · 2018Article
- Circadian Rhythms inACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2017Article
- Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation.PLoS computational biology · 2017Article
- Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator.PLoS computational biology · 2016Article
- Protein sequestration versus Hill-type repression in circadian clock models.IET systems biology · 2016Review
- Understanding environmental adaptation of the fungal circadian clock with mathematical modeling.Biophysical journal · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autonomous circadian oscillations arise from transcriptional-translational feedback loops of core clock components. The period of a circadian oscillator is relatively insensitive to changes in nutrients (e.g., glucose), which is referred to as "nutrient compensation". Recently, a transcription repressor, CSP-1, was identified as a component of the circadian system in Neurospora crassa. The transcription of csp-1 is under the circadian regulation. Intriguingly, CSP-1 represses the circadian transcription factor, WC-1, forming a negative feedback loop that can influence the core oscillator. This feedback mechanism is suggested to maintain the circadian period in a wide range of glucose concentrations. In this report, we constructed a mathematical model of the Neurospora circadian clock incorporating the above WC-1/CSP-1 feedback loop, and investigated molecular mechanisms of glucose compensation. Our model shows that glucose compensation exists within a narrow range of parameter space where the activation rates of csp-1 and wc-1 are balanced with each other, and simulates loss of glucose compensation in csp-1 mutants. More importantly, we experimentally validated rhythmic oscillations of the wc-1 gene expression and loss of glucose compensation in the wc-1(ov) mutant as predicted in the model. Furthermore, our stochastic simulations demonstrate that the CSP-1-dependent negative feedback loop functions in glucose compensation, but does not enhance the overall robustness of oscillations against molecular noise. Our work highlights predictive modeling of circadian clock machinery and experimental validations employing Neurospora and brings a deeper understanding of molecular mechanisms of glucose compensation.
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