ArticleBiophysical journal2015
Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Article
- Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine.Innovation (Cambridge (Mass.)) · 2026Review
- Targeting integrin αVβ3-Ptgs2-mTOR signaling rescues bone formation in osteoporosis: from molecular mechanism toward therapy.Cellular & molecular biology letters · 2026Article
- Deep learning models to map osteocyte networks from confocal microscopy can successfully distinguish between young and aged bone.PLoS computational biology · 2026Article
- Hypotonic stimuli promote osteocyte dendrite formation by modulating actin dynamics via the TRPV4-CDC42 signaling pathway.Materials today. Bio · 2025Article
- Differential gene expression in trabecular bone osteocytes is related to the local strain and strain gradient.Scientific reports · 2025Article
- Mechanical deformations of bone generate interstitial fluid flow at nanoscale velocities around osteocytes.Frontiers in bioengineering and biotechnology · 2025Article
- Air Pollution and Osteoporosis.Current osteoporosis reports · 2024Review
- Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiency.JBMR plus · 2024Article
- Computational modeling based on confocal imaging predicts changes in osteocyte and dendrite shear stress due to canalicular loss with aging.Biomechanics and modeling in mechanobiology · 2024Article
- A Novel Primary Cilium-Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Osteocytes and Primary Cilia.Current osteoporosis reports · 2023Review
- Fluid flow shear stress and tissue remodeling-an orthodontic perspective: evidence synthesis and differential gene expression network analysis.Frontiers in bioengineering and biotechnology · 2023Article
- Temporal changes in cortical microporosity during estrogen deficiency associated with perilacunar resorption and osteocyte apoptosis: A pilot study.Bone reports · 2022Article
- Fenoldopam Sensitizes Primary Cilia-Mediated Mechanosensing to Promote Osteogenic Intercellular Signaling and Whole Bone Adaptation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Osteocytes and Estrogen Deficiency.Current osteoporosis reports · 2021Review
- Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States.Frontiers in cell and developmental biology · 2021Review
- The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecture.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in bone tissue composition during osteoporosis likely disrupt the mechanical environment of bone cells and may thereby initiate a mechanobiological response. It has proved challenging to characterize the mechanical environment of bone cells in vivo, and the mechanical environment of osteoporotic bone cells is not known. The objective of this research is to characterize the local mechanical environment of osteocytes and osteoblasts from healthy and osteoporotic bone in a rat model of osteoporosis. Using a custom-designed micromechanical loading device, we apply strains representative of a range of physical activity (up to 3000 με) to fluorescently stained femur samples from normal and ovariectomized rats. Confocal imaging was simultaneously performed, and digital image correlation techniques were applied to characterize cellular strains. In healthy bone tissue, osteocytes experience higher maximum strains (31,028 ± 4213 με) than osteoblasts (24,921 ± 3,832 με), whereas a larger proportion of the osteoblast experiences strains >10,000 με. Most interestingly, we show that osteoporotic bone cells experience similar or higher maximum strains than healthy bone cells after short durations of estrogen deficiency (5 weeks), and exceeded the osteogenic strain threshold (10,000 με) in a similar or significantly larger proportion of the cell (osteoblast, 12.68% vs. 13.68%; osteocyte, 15.74% vs. 5.37%). However, in long-term estrogen deficiency (34 weeks), there was no significant difference between bone cells in healthy and osteoporotic bone. These results suggest that the mechanical environment of bone cells is altered during early-stage osteoporosis, and that mechanobiological responses act to restore the mechanical environment of the bone tissue after it has been perturbed by ovariectomy.
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