Evidence map›Paper›PMID 25862932›Full record

ArticleStructure (London, England : 1993)2015

Splicing and proteolytic processing in VEGF signaling: now it is the coreceptor's turn.

Xiaolan Yao, Samuel Bouyain

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Structure (London, England : 1993), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Hes1 attenuates type I IFN responses via VEGF-C and WDFY1.The Journal of experimental medicine · 2019
    Article
  2. Alternative Splicing in Angiogenesis.International journal of molecular sciences · 2019
    Review
  3. Neuropilin Functions as an Essential Cell Surface Receptor.The Journal of biological chemistry · 2015
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiaolan YaoDivision of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA.
Samuel BouyainDivision of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA; Department of Neurology and Cognitive Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA. Electronic address: bouyains@umkc.edu.
University of Missouri–Kansas City · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative splicing and proteolytic processing of VEGFs generate proteins with distinct physiological roles. In this issue of Structure, Parker et al. show that proteolysis of an isoform of the VEGF-C coreceptor Nrp2 produces a soluble receptor that inhibits VEGF-C/Nrp2 interactions.

Indexed as

HumansNeuropilin-2Vascular Endothelial Growth Factor CNeuropilin-2Vascular Endothelial Growth Factor C

Identifiers

PMID25862932
OpenAlexW2019731667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.