ArticleMolecular systems biology2015
A growth-rate composition formula for the growth of E.coli on co-utilized carbon substrates.
Article in Molecular systems biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Thermodynamic Evaluation of Dual Substrate Growth.Biotechnology and bioengineering · 2026Article
- Fitness advantage of sequential metabolic strategies emerges from community interactions in strongly fluctuating environments.PLoS computational biology · 2026Article
- A proteome optimal allocation model for elucidating effects of temperature on bacterial growth.NPJ systems biology and applications · 2026Article
- Resource diversity and supply drive colonization resistance.PLoS computational biology · 2025Article
- Overflow metabolism in bacterial, yeast, and mammalian cells: different names, same game.Molecular systems biology · 2025Review
- Global constraint principle for microbial growth laws.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources.mSystems · 2025Article
- Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering.Cell host & microbe · 2025Review
- Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli.Nature communications · 2025Article
- Article
- A parallel glycolysis provides a selective advantage through rapid growth acceleration.Nature chemical biology · 2024Article
- Functional decomposition of metabolism allows a system-level quantification of fluxes and protein allocation towards specific metabolic functions.Nature communications · 2023Article
- Shaping bacterial gene expression by physiological and proteome allocation constraints.Nature reviews. Microbiology · 2023Review
- Diauxic lags explain unexpected coexistence in multi-resource environments.Molecular systems biology · 2022Article
- Overcoming glutamate auxotrophy inMetabolic engineering communications · 2021Article
- Suboptimal resource allocation in changing environments constrains response and growth in bacteria.Molecular systems biology · 2021Article
- Hierarchical and simultaneous utilization of carbon substrates: mechanistic insights, physiological roles, and ecological consequences.Current opinion in microbiology · 2021Review
- Escherichia coli segments its controls on carbon-dependent gene expression into global and specific regulations.Microbial biotechnology · 2021Article
- Constrained proteome allocation affects coexistence in models of competitive microbial communities.The ISME journal · 2021Article
- Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments.Molecular systems biology · 2021Article
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Authors and funding
5 authors.
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Abstract
When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates are co-utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.