Evidence map›Paper›PMID 25862743›Full record

Trial reportCirculation2015

Gender differences in the trajectory of recovery in health status among young patients with acute myocardial infarction: results from the variation in recovery: role of gender on outcomes of young AMI patients (VIRGO) study.

Rachel P Dreyer, Yongfei Wang, Kelly M Strait, Nancy P Lorenze, Gail D'Onofrio, Héctor Bueno, Judith H Lichtman, John A Spertus, Harlan M Krumholz

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Predicting Return to Work Following Myocardial Infarction: A Prospective Longitudinal Cohort Study.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel P DreyerFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.). rachel.dreyer@yale.edu.
Yongfei WangFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.).
Kelly M StraitFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.).
Nancy P LorenzeFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.).
Gail D'OnofrioFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.).
Héctor BuenoFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.).
Judith H LichtmanFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.).
John A SpertusFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.).
Harlan M KrumholzFrom the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (R.P.D., Y.W., K.M.S., N.P.L., J.H.L., H.M.K.); Section of Cardiovascular Medicine (R.P.D., Y.W., H.M.K.) and the Robert Wood Johnson Foundation Clinical Scholars Program (H.M.K.), and Department of Emergency Medicine (G.D.), Yale School of Medicine, New Haven, CT; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, and Universidad Complutense de Madrid, Spain (H.B.); Departments of Chronic Disease Epidemiology (J.H.L.) and Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri, Kansas City, School of Medicine, Biomedical & Health Informatics (J.A.S.); and Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.).

Funding

Young Women With Acute Myocardial InfarctionR01HL081153 · NHLBI · YALE UNIVERSITY · PI KRUMHOLZ, HARLAN MARC · 2007 to 2012
$10.6M
Center for Cardiovascular Outcomes Research at Yale UniversityU01HL105270 · NHLBI · YALE UNIVERSITY · PI CURTIS, JEPTHA PELHAM, KRUMHOLZ, HARLAN MARC · 2010 to 2013
$5.8M
NHLBI NIH HHS 5R01HL081153NHLBI NIH HHS R01 HL081153NHLBI NIH HHS U01 HL105270NHLBI NIH HHS U01 HL105270-05
6 · The paper itself

Abstract

backgroundDespite the excess risk of mortality in young women (≤55 years of age) after acute myocardial infarction (AMI), little is known about young women's health status (symptoms, functioning, quality of life) during the first year of recovery after an AMI. We examined gender differences in health status over time from baseline to 12 months after AMI. METHODS AND

resultsA total of 3501 AMI patients (67% women) 18 to 55 years of age were enrolled from 103 US and 24 Spanish hospitals. Data were obtained by medical record abstraction and patient interviews at baseline hospitalization and 1 and 12 months after AMI. Health status was measured by generic (Short Form-12) and disease-specific (Seattle Angina Questionnaire) measures. We compared health status scores at all 3 time points and used longitudinal linear mixed-effects analyses to examine the independent effect of gender, adjusting for time and selected covariates. Women had significantly lower health status scores than men at each assessment (all P values <0.0001). After adjustment for time and all covariates, women had Short Form-12 physical/mental summary scores that were -0.96 (95% confidence interval [CI], -1.59 to -0.32) and -2.36 points (95% CI, -2.99 to -1.73) lower than those of men, as well as worse Seattle Angina Questionnaire physical limitations (-2.44 points lower; 95% CI, -3.53 to -1.34), more angina (-1.03 points lower; 95% CI, -1.98 to -0.07), and poorer quality of life (-3.51 points lower; 95% CI, -4.80 to -2.22).

conclusionAlthough both genders recover similarly after AMI, women have poorer scores than men on all health status measures, a difference that persisted throughout the entire year after discharge.

Indexed as

Health StatusRecovery of FunctionSex CharacteristicsAdultFemaleHumansLongitudinal StudiesMaleMiddle AgedMortalityMyocardial InfarctionProspective StudiesRisk FactorsSurveys and QuestionnairesTime FactorsTreatment Outcomegender characteristicshealth statusmyocardial infarctionprognosiswomen

Identifiers

PMID25862743
PMCPMC4657729

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.