Evidence map›Paper›PMID 25862705›Full record

Trial reportHaematologica2015

Fine tuning of surface CRLF2 expression and its associated signaling profile in childhood B-cell precursor acute lymphoblastic leukemia.

Cristina Bugarin, Jolanda Sarno, Chiara Palmi, Angela Maria Savino, Geertruy te Kronnie, Michael Dworzak, Angela Shumich, Barbara Buldini, Oscar Maglia, Simona Sala and 11 more

Open access · goldAbstract readClinical TrialLetterMulticenter Study
In one paragraph

Trial report in Haematologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Genetics of B-Cell Acute Lymphoblastic Leukemia (B-ALL): Recent Updates and Indian Perspective.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Review
  2. Article
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  5. Frontiers in cell and developmental biology · 2022
    Review
  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 5 countries.

Cristina BugarinPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy.
Jolanda SarnoPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy.
Chiara PalmiPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy.
Angela Maria SavinoPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy.
Geertruy te KronnieLab. Hemato-Oncology, University of Padua, Italy.
Michael DworzakChildren's Cancer Research Institute and St. Anna Children's Hospital, Dept. of Pediatrics, Medical University of Vienna, Austria.
Angela ShumichChildren's Cancer Research Institute and St. Anna Children's Hospital, Dept. of Pediatrics, Medical University of Vienna, Austria.
Barbara BuldiniLab. Hemato-Oncology, University of Padua, Italy.
Oscar MagliaPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy.
Simona SalaPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy.
Ilaria BronziniLab. Hemato-Oncology, University of Padua, Italy.
Jean-Pierre BourquinUniversity of Zurich, Switzerland.
Ester MejstrikovaChildhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Charles University Prague, 2 Medical School, Czech Republic.
Ondrej HrusakChildhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Charles University Prague, 2 Medical School, Czech Republic.
Drorit LuriaPediatric Hematology Oncology, Schneider Children's Medical Center of Israel.
Giuseppe BassoLab. Hemato-Oncology, University of Padua, Italy.
Shai IzraeliPediatric Hematology Oncology, Schneider Children's Medical Center of Israel.
Andrea BiondiPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy Department of Pediatrics, Hospital San Gerardo/Fondazione MBBM, Monza, Italy abiondi.unimib@gmail.com andrea.biondi@unimib.it.
Giovanni CazzanigaPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy.
Giuseppe GaipaPediatric Clinic, University of Milano Bicocca, M. Tettamanti Research Center, Monza, Italy.
I-BFM study group
University of Milano-Bicocca · ITUniversity of Padua · ITCharles University · CZSchneider Children's Medical Center · ILSt Anna Children's Hospital · ATUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, LeukemicBiomarkers, TumorChildChild, PreschoolFemaleHumansMalePrecursor B-Cell Lymphoblastic Leukemia-LymphomaReceptors, CytokineSignal TransductionBiomarkers, TumorCRLF2 protein, humanReceptors, Cytokinechildhood ALLCRLF2flow cytometryJAK/STAT

Identifiers

PMID25862705
PMCPMC4450636
OpenAlexW2073878519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.