ArticleHNO2015
Stress and tinnitus.
Article in HNO, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06718452 (Treatment of Tinnitus Targeting Neuroinflammation. umPEALUT as Possible Option), which is not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Tinnitus Targeting Neuroinflammation. umPEALUT as Possible Option
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Smartphone Apps in the Context of Tinnitus: Systematic Review.Sensors (Basel, Switzerland) · 2020Pooled it
- Cognitive behavioural therapy for tinnitus.The Cochrane database of systematic reviews · 2020Pooled it
- A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment.HNO · 2019Guideline
- Smartphone-Based Cognitive Behavioral Therapy and Customized Sound Therapy for Tinnitus: A Randomized Controlled Trial.The Annals of otology, rhinology, and laryngology · 2025Trial
- Prevalence and severity of tinnitus in Polish otosclerosis patients qualified for stapes surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Trial
- Combined Bioinformatic Analysis and RNA Sequencing Uncover Key Tinnitus-Related Molecules in the Cingulate Gyrus.International journal of molecular sciences · 2026Article
- Review
- Psychosocial Work Stress, Resilience and the Risk of Tinnitus-Results from a Population-Based Cohort Study.Medicina (Kaunas, Lithuania) · 2025Observational
- An Insight into Role of Auditory Brainstem in Tinnitus: A Systematic Review of Diagnostic Assessments.Audiology research · 2025Review
- Trajectory of Tinnitus Distress Across the COVID-19 Pandemic: A Cross-Sectional Analysis of Self-Reported Symptoms.Audiology research · 2025Article
- When the Mind Meets the Ear: A Scoping Review on Tinnitus and Clinically Measured Psychiatric Comorbidities.Journal of clinical medicine · 2025Review
- Review
- Tinnitus Generation and Behavioral Changes Caused by Chronic Stress: A Behavioral and Brain Study in a Rat Model.The Laryngoscope · 2025Article
- Enhanced response and safety of combining dunhuang 'moxibustion classic' acupuncture with carbamazepine in treating neuropathic tinnitus and identifying risk factors affecting sleep quality.American journal of translational research · 2024Article
- The role of stimuli of life events and sleep quality in the incidence of acute low-tone sensorineural hearing loss.Frontiers in neurology · 2024Article
- The quality and reliability of patient education regarding sound therapy videos for tinnitus on YouTube.PeerJ · 2024Article
- Rasch Analysis of the Korean Version of the Tinnitus Handicap Inventory.Journal of clinical medicine · 2023Article
- Limited Link of Common Blood Parameters with Tinnitus.Journal of clinical medicine · 2023Article
- Tinnitus and Influencing Comorbidities.Laryngo- rhino- otologie · 2023Review
- The association between stress, emotional states, and tinnitus: a mini-review.Frontiers in aging neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emotional stress is a constant companion of tinnitus patients, since this phantom sound can unfortunately be a very effective stressor. However, the mechanism of stress contribution to the onset or progression of tinnitus remains unknown. Here, we review the pathways induced by emotional stress and the outcome of their induction: corticosteroid-dependent changes in gene expression, epigenetic modulations, and impact of stress on neuronal plasticity and neurotransmission. Using clinical examples, we demonstrate the presence of emotional stress among tinnitus patients and we present methods to measure the degree of stress. The evidence causally linking emotional stress with tinnitus is still indirect-the main difficulty lies in the inaccessibility of human auditory tissues and the inability to directly measure tinnitus-induced psychological distress in animal models. However, we believe that translational research is the future way of filling this gap, finding the answers, and thereby improving both the diagnosis and treatment of tinnitus patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.