ArticleJournal of neurology2015
Identification of cortical lesions using DIR and FLAIR in early stages of multiple sclerosis.
Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Neuroimaging markers and disability scales in multiple sclerosis: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Superiority of 3D-DIR over 3D-FLAIR in the Detection of Cortical Lesions and Correlation with Disability in Multiple Sclerosis: A Multicenter Study.Diagnostics (Basel, Switzerland) · 2025Article
- Large-scale online assessment uncovers a distinct Multiple Sclerosis subtype with selective cognitive impairment.Nature communications · 2025Article
- Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2024Review
- Inflammatory mechanisms underlying cortical injury in progressive multiple sclerosis.Neuroimmunology and neuroinflammation · 2021Article
- Cognitive Dysfunction in the Early Stages of Multiple Sclerosis-How Much and How Important?Current neurology and neuroscience reports · 2020Review
- Optimizing 3D FLAIR to detect MS lesions: pushing past factory settings for precise results.Journal of neurology · 2019Article
- Cerebrospinal fluid T1 value phantom reproduction at scan room temperature.Journal of applied clinical medical physics · 2019Article
- Evaluation the FLAIR Sensitivity and DWI Post-inject in Comparison with Delayed Enhancement T1w for Better Detection of Active MS Lesions.Journal of biomedical physics & engineering · 2018Article
- Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study.Brain and behavior · 2018Article
- Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study.Neuropsychiatric disease and treatment · 2017Article
- 3D-DIR for early differential diagnostic and prognostic evaluation of NMO.Experimental and therapeutic medicine · 2016Article
- The Contribution of Cortical Lesions to a Composite MRI Scale of Disease Severity in Multiple Sclerosis.Frontiers in neurology · 2016Article
- Interrater reliability for the detection of cortical lesions on phase-sensitive inversion recovery magnetic resonance imaging in patients with multiple sclerosis.Radiologia brasileiraArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of non-routine MRI sequences such as DIR has highlighted the role of gray matter (GM) pathology in multiple sclerosis (MS). The aim of this study was to assess the detection and relevance of cortical lesions (CLs) using MRI in early (<5 years) MS patients. 3D DIR and 3D FLAIR images at 3T from 122 patients [93 relapsing-remitting MS (RRMS), 29 clinically isolated syndrome (CIS)] were scored for CLs by two blinded readers. Patients were divided into two groups depending on the presence or absence of CLs. For FLAIR, 51 CLs were identified, of which 13 were purely intracortical and 38 mixed CLs; for DIR, this was 60 in total and 16 and 44, respectively. In both groups, there was no difference in GM fraction. Neuropsychological testing was performed for a subgroup of 66 patients. In 22.1 % of patients CLs were identified. The number of CLs revealed an association with lower working memory scores and semantical word fluency. Overall, CLs imaged with 3D FLAIR and 3D DIR sequences are found more frequently in RRMS patients than CIS and may also be a correlate for mild neuropsychological pathology.
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