ArticleCancer research2015
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.
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Article in Cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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38citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.Nature genetics · 2016Pooled it
- A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density.Breast cancer research : BCR · 2015Pooled it
- Genome-wide association study of Asian women identifies putative mammographic density-associated loci.Breast cancer research : BCR · 2025Article
- Constructing shared genetic architecture between bioavailable testosterone and luminal A breast cancer in female.Breast cancer (Tokyo, Japan) · 2025Article
- Advances in Research on the B-Lineage Transcription Factor EBF1 in Solid Tumors.International journal of molecular sciences · 2025Review
- Association between breastfeeding, mammographic density, and breast cancer risk: a review.International breastfeeding journal · 2024Review
- Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening.Clinics and practice · 2024Article
- Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia.Breast cancer research and treatment · 2023Article
- The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulatingScience advances · 2022Article
- Article
- Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases.International journal of molecular sciences · 2022Review
- The epidemiologic factors associated with breast density: A review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Review
- Article
- Heritability of mammographic breast density.Quantitative imaging in medicine and surgery · 2020Article
- The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study.Acta radiologica (Stockholm, Sweden : 1987) · 2020Article
- Challenges and emerging systems biology approaches to discover how the human gut microbiome impact host physiology.Biophysical reviews · 2020Review
- Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation associated gene expression in patients with colorectal cancer.BMC microbiology · 2020Article
- Going Beyond Conventional Mammographic Density to Discover Novel Mammogram-Based Predictors of Breast Cancer Risk.Journal of clinical medicine · 2020Article
- Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast.NPJ breast cancer · 2020Article
- Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk.Breast cancer research : BCR · 2019Article
Corrections and comments
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Authors and funding
60 authors at 1 institution in 1 country.
Jennifer StoneCentre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia.
Deborah J ThompsonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Isabel Dos Santos SilvaDepartment of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Christopher ScottDepartment of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.
Rulla M TamimiChanning Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Sara LindstromDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Aditi HazraDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Jingmei LiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Louise ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Matt JensenDepartment of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.
Julie CunninghamDepartment of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Janet E OlsonDepartment of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.
Kristen PurringtonDepartment of Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota. Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.
Judith BrownCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Jean LeylandCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Ruth M L WarrenDepartment of Radiology, University of Cambridge, Addenbrooke's NHS Foundation Trust, Cambridge, United Kingdom.
Robert N LubenDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Kay-Tee KhawMRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), University of Cambridge, Cambridge, United Kingdom.
Paula SmithDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Sebastian M JudUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.
Katharina HeusingerUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.
Matthias W BeckmannUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.
Julie A DouglasDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan.
Kaanan P ShahDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan.
Heang-Ping ChanDepartment of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.
Mark A HelvieDepartment of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, Hawaii.
Laurence N KolonelUniversity of Hawaii Cancer Center, Honolulu, Hawaii.
Christy WoolcottDepartment of Obstetrics and Genecology, IWK Health Centre, Halifax, Canada.
Gertraud MaskarinecUniversity of Hawaii Cancer Center, Honolulu, Hawaii.
Christopher HaimanKeck School of Medicine, University of Southern California, Los Angeles, California.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Laura BagliettoCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Centre for Research in Epidemiology and Population Health, Gustave Roussy Institute, Villejuif Cedex, France. Paris-South University, Villejuif, France.
Kavitha KrishnanCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Melissa C SoutheyDepartment of Pathology, University of Melbourne, Melbourne, Australia.
Carmel ApicellaCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Irene L AndrulisCenter for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Julia A KnightProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Giske UrsinInstitute of Basic Medical Sciences, University of Oslo, Norway. Department of Preventive Medicine, University of Southern California, California.
Grethe I Grenaker AlnaesDepartment of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
Vessela N KristensenDepartment of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
Anne-Lise Borresen-DaleDepartment of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
Inger Torhild GramFaculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Qin WangFaculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Jacques SimardCentre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.
Paul PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Peter A FaschingUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen-Nuremberg, Germany. Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
V Shane PankratzDepartment of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Celine M VachonDepartment of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota. vachon.celine@mayo.edu.
Karolinska Institutet · SE
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MThe Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2005 to 2026
$49.9MVariation in Receptor Tyrosine Kinases and Breast Cancer RiskP50CA089393 · NCI · DANA-FARBER CANCER INSTITUTE · PI WINER, ERIC P · 2000 to 2009
$28.8MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MUniversity of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MBreast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7MBIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3MCharacterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098233 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNTER, DAVID JOHN · 2003 to 2010
$10.8MEpidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6MEpidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4MCancer Research UK 10119Cancer Research UK 10124Cancer Research UK 14136Cancer Research UK 14565Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK C12292/A11174Cancer Research UK C1281/A12014Cancer Research UK C1287/A10118Cancer Research UK C1287/A 10710Cancer Research UK C5047/A10692Cancer Research UK C5047/A15007Cancer Research UK C5047/A8384CIHRMedical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1NCI NIH HHS 1U19 CA148065NCI NIH HHS 1U19CA148112NCI NIH HHS 1U19 CA148537NCI NIH HHS CA049449NCI NIH HHS CA087969NCI NIH HHS CA089393NCI NIH HHS CA116201NCI NIH HHS CA122340NCI NIH HHS CA122822NCI NIH HHS CA128931NCI NIH HHS CA128978NCI NIH HHS CA131332NCI NIH HHS CA98233NCI NIH HHS K01 CA122822NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA15083NCI NIH HHS P50 CA089393NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA063464NCI NIH HHS R01CA063464NCI NIH HHS R01 CA085265NCI NIH HHS R01CA085265NCI NIH HHS R01 CA097396NCI NIH HHS R01 CA122340NCI NIH HHS R01 CA122844NCI NIH HHS R01 CA128931NCI NIH HHS R01CA128931NCI NIH HHS R01 CA 128931-S01NCI NIH HHS R01 CA128931-S01NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA131332NCI NIH HHS R01 CA132839NCI NIH HHS R01CA132839NCI NIH HHS R01 CA97396NCI NIH HHS R25 CA090956NCI NIH HHS R25CA090956NCI NIH HHS R25 CA174664NCI NIH HHS R37 CA054281NCI NIH HHS R37CA054281NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA098233NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS T32 HG000040NHGRI NIH HHS X01 HG005954
Abstract
Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk, but few mammographic density-associated genetic variants have been identified. Using data for 10,727 women from two international consortia, we estimated associations between 77 common breast cancer susceptibility variants and absolute dense area, percent dense area and absolute nondense area adjusted for study, age, and BMI using mixed linear modeling. We found strong support for established associations between rs10995190 (in the region of ZNF365), rs2046210 (ESR1), and rs3817198 (LSP1) and adjusted absolute and percent dense areas (all P < 10(-5)). Of 41 recently discovered breast cancer susceptibility variants, associations were found between rs1432679 (EBF1), rs17817449 (MIR1972-2: FTO), rs12710696 (2p24.1), and rs3757318 (ESR1) and adjusted absolute and percent dense areas, respectively. There were associations between rs6001930 (MKL1) and both adjusted absolute dense and nondense areas, and between rs17356907 (NTN4) and adjusted absolute nondense area. Trends in all but two associations were consistent with those for breast cancer risk. Results suggested that 18% of breast cancer susceptibility variants were associated with at least one mammographic density measure. Genetic variants at multiple loci were associated with both breast cancer risk and the mammographic density measures. Further understanding of the underlying mechanisms at these loci could help identify etiologic pathways implicated in how mammographic density predicts breast cancer risk.
Indexed as
AgedBreast DensityBreast NeoplasmsDisease SusceptibilityFemaleGenetic Predisposition to DiseaseGenotypeHumansMammary Glands, HumanMiddle AgedPolymorphism, Single NucleotideRisk Factors
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