ArticleNeuroImage2015
Understanding the dynamic relationship between cerebral blood flow and the BOLD signal: Implications for quantitative functional MRI.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trial.Psychopharmacology · 2026Trial
- Opioidergic modulation of monetary incentive delay fMRI responses.Psychopharmacology · 2025Trial
- The effect of risperidone on reward-related brain activity is robust to drug-induced vascular changes.Human brain mapping · 2021Trial
- Resting-state brain function and its modulation by intranasal oxytocin in antisocial personality disorder with and without psychopathy.Scientific reports · 2026Article
- Temporal fluctuation in lateral ventricle volume and its coupling with CSF inflow and global BOLD signal.Scientific reports · 2025Article
- Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.Communications biology · 2025Article
- Tobacco Smoking Functional Networks: A Whole-Brain Connectome Analysis in 24 539 Individuals.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer's disease.Communications biology · 2024Article
- The temporal specificity of BOLD fMRI is systematically related to anatomical and vascular features of the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Revealing the combined roles of Aβ and tau in Alzheimer's disease via a pathophysiological activity decoder.bioRxiv : the preprint server for biology · 2023Article
- Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response.Progress in neurobiology · 2021Review
- Resting cerebral oxygen metabolism exhibits archetypal network features.Human brain mapping · 2021Article
- Developmental patterns of CBF and BOLD responses to visual stimulus.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Imaging brain function with simultaneous BOLD and viscoelasticity contrast: fMRI/fMRE.NeuroImage · 2020Article
- Altered subcortical emotional salience processing differentiates Parkinson's patients with and without psychotic symptoms.NeuroImage. Clinical · 2020Article
- Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep.Science (New York, N.Y.) · 2019Article
- Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRNeuroImage · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Calibrated BOLD imaging, in which traditional measurements of the BOLD signal are combined with measurements of cerebral blood flow (CBF) within a BOLD biophysical model to estimate changes in oxygen metabolism (CMRO2), has been a valuable tool for untangling the physiological processes associated with neural stimulus-induced BOLD activation. However, to date this technique has largely been applied to the study of essentially steady-state physiological changes (baseline to activation) associated with block-design stimuli, and it is unclear whether this approach may be directly extended to the study of more dynamic, naturalistic experimental designs. In this study we tested an assumption underlying this technique whose validity is critical to the application of calibrated BOLD to the study of more dynamic stimuli, that information about fluctuations in venous cerebral blood volume (CBVv) can be captured indirectly by measuring fluctuations in CBF, making the independent measurement of CBVv unnecessary. To accomplish this, simultaneous arterial spin labeling and BOLD imaging were used to measure the CBF and BOLD responses to flickering checkerboards with contrasts that oscillated continuously with frequencies of ~0.02-0.16Hz. The measurements were then fit to a dynamic physiological model of the BOLD response in order to explore the range of consistent CMRO2 and CBVv responses. We found that the BOLD and CBF responses were most consistent with relatively tight dynamic coupling between CBF and CMRO2 and a CBVv response that was an order of magnitude slower than either CBF or CMRO2. This finding suggests that the assumption of tight flow-volume coupling may not be strictly valid, complicating the extension of calibrated BOLD to more naturalistic experimental designs.
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Registered trials
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