Evidence map›Paper›PMID 25862266›Full record

ArticleNeuroImage2015

Decreases in theta and increases in high frequency activity underlie associative memory encoding.

Jeffrey A Greenberg, John F Burke, Rafi Haque, Michael J Kahana, Kareem A Zaghloul

Abstract read
In one paragraph

Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Hippocampal CA1 gamma power predicts the precision of spatial memory judgments.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Trial
  4. Article
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  10. Intracerebral Dynamics of Sleep Arousals: A Combined Scalp-Intracranial EEG Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Article
  12. Study on the Effect ofMolecules (Basel, Switzerland) · 2024
    Article
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  16. Review
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  20. Hippocampal activity predicts contextual misattribution of false memories.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeffrey A GreenbergDepartment of Psychology, University of Pennsylvania, 19104, USA.
John F BurkeDepartment of Psychology, University of Pennsylvania, 19104, USA.
Rafi HaqueSurgical Neurology Branch, NINDS, National Institutes of Health, 20892, USA.
Michael J KahanaDepartment of Psychology, University of Pennsylvania, 19104, USA.
Kareem A ZaghloulSurgical Neurology Branch, NINDS, National Institutes of Health, 20892, USA. Electronic address: kareem.zaghloul@nih.gov.

Funding

Investigating the neural mechanisms of human cognitive function through intracranial recordingsZIANS003144 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ZAGHLOUL, KAREEM · 2014 to 2025
$36.1M
Associative Processes in Episodic MemoryR01MH055687 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KAHANA, MICHAEL JACOB · 2002 to 2024
$7.9M
Intracranial Recordings Reveal Task Dependent ThetaR01MH061975 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KAHANA, MICHAEL JACOB · 2002 to 2018
$5.2M
TRAINING PROGRAM IN BEHAVIORAL/COGNITIVE NEUROSCIENCET32MH017168 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KABLE, JOSEPH W · 1985 to 2018
$4.2M
Intracranial EEG for Neuronal Oscillatory Contingency during Cognitive TasksR21NS067316 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAHANA, MICHAEL JACOB · 2009 to 2010
$473k
MATHEMATICAL MODELS OF HUMAN MEMORYR29MH055687 · NIMH · BRANDEIS UNIVERSITY · PI KAHANA, MICHAEL JACOB · 1997 to 2001
$218k
Intramural NIH HHS ZIA NS003144NIMH NIH HHS MH017168NIMH NIH HHS MH055687NIMH NIH HHS MH061975NIMH NIH HHS R01 MH055687NIMH NIH HHS R01 MH061975NIMH NIH HHS R29 MH055687NIMH NIH HHS T32 MH017168NINDS NIH HHS NS067316NINDS NIH HHS R21 NS067316
6 · The paper itself

Abstract

Episodic memory encoding refers to the cognitive process by which items and their associated contexts are stored in memory. To investigate changes directly attributed to the formation of explicit associations, we examined oscillatory power captured through intracranial electroencephalography (iEEG) as 27 neurosurgical patients receiving subdural and depth electrodes for seizure monitoring participated in a paired associates memory task. We examined low (3-8Hz) and high (45-95Hz) frequency activity, and found that the successful formation of new associations was accompanied by broad decreases in low frequency activity and a posterior to anterior progression of increases in high frequency activity in the left hemisphere. These data suggest that the observed patterns of activity may reflect the neural mechanisms underlying the formation of novel item-item associations.

Indexed as

Brain WavesMemory, EpisodicAdultAssociation LearningBrainElectroencephalographyFemaleHumansMaleMiddle AgedTheta RhythmYoung AdultAssociative memory encodingEpisodic memoryiEEGSubsequent memory effect

Identifiers

PMID25862266
PMCPMC4446176

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.