Evidence map›Paper›PMID 25862009›Full record

ReviewJournal of neuro-oncology2015

Anaplastic ganglioglioma: a report of three cases and review of the literature.

John Thomas Lucas, Andrew Jonathan Huang, Ryan T Mott, Glenn J Lesser, Stephen Bradley Tatter, Michael David Chan

Abstract readCase ReportsReview
In one paragraph

Review in Journal of neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Imaging of pediatric glioneuronal and neuronal tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Benign Glioma.Advances in experimental medicine and biology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Impact of surgery, adjuvant treatment, and other prognostic factors in the management of anaplastic ganglioglioma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Article
  13. A case of adult anaplastic cerebellar ganglioglioma.Surgical neurology international · 2018
    Article
  14. Pediatric intracranial primary anaplastic ganglioglioma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017
    Article
  15. Awake surgery for hemispheric low-grade gliomas: oncological, functional and methodological differences between pediatric and adult populations.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016
    Review
  16. Article
  17. Practical aspects regarding the histopathological grading and anaplastic transformation of gangliogliomas - a literature review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

John Thomas LucasDepartment of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA, johnthomas75@gmail.com.
Andrew Jonathan Huang
Ryan T Mott
Glenn J Lesser
Stephen Bradley Tatter
Michael David Chan
Wake Forest University · USAtrium Health Wake Forest Baptist · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
NCI NIH HHS P30 CA012197
6 · The paper itself

Abstract

Gangliogliomas are rare tumors of the central nervous system that are thought to arise from a glioneuronal precursor and consist of both neuronal and glial elements. Grade III, or anaplastic ganglioglioma (AGG), most commonly affects children and young adults, generally arises in a supratentorial location, is highly epileptogenic, and often results in diffuse local and distant failure within the craniospinal axis. Pathologically, these tumors are graded by the degree of malignancy in their glial portion and radiologic diagnosis is difficult due to the wide variation in its degree of solid and cystic components, contrast uptake, and calcification patterns. This report presents three cases of AGG, with initial treatment including subtotal resection followed by conformal radiotherapy. In the case where the AGG developed in the setting of an existent low-grade astrocytoma, the patient received no chemotherapy. Both of the other de novo cases were managed with adjuvant chemoradiotherapy with temozolomide. Recurrence occurred at 6, 16, and 20 months following therapy. Two of the three patients experienced symptomatic decline at recurrence, but experienced Karnofsky performance status (KPS) improvement after salvage therapy, including the reduction of cranial neuropathy and balance. All patients had a significant reduction in presenting symptoms following salvage therapy. Patients died at 23, 20, and 22 months following initial surgical management, respectively. A review of anaplastic and malignant gangliogliomas is presented in the context of these three cases.

Indexed as

AdultBrain NeoplasmsChildCombined Modality TherapyGangliogliomaHumansMagnetic Resonance ImagingMaleNeoplasm Recurrence, LocalNeoplasm StagingPrognosisSalvage Therapy

Identifiers

PMID25862009
PMCPMC4471868
OpenAlexW2082473326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.