Evidence map›Paper›PMID 25861811›Full record

ArticleHuman molecular genetics2015

A common variant near TGFBR3 is associated with primary open angle glaucoma.

Zheng Li, R Rand Allingham, Masakazu Nakano, Liyun Jia, Yuhong Chen, Yoko Ikeda, Baskaran Mani, Li-Jia Chen, Changwon Kee, David F Garway-Heath and 103 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 7 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 7 syntheses or guidelines pooled it, 117 citations in OpenAlex.

  1. Pooled it
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  15. Homocysteine and Glaucoma.International journal of molecular sciences · 2023
    Review
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

113 authors at 20 institutions in 14 countries.

Zheng LiSingapore Eye Research Institute, Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
R Rand AllinghamDepartment of Ophthalmology, Duke University Eye Center, Durham, NC, USA.
Masakazu NakanoDepartment of Genomic Medical Sciences.
Liyun JiaBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yuhong ChenDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School.
Yoko IkedaDepartment of Ophthalmology.
Baskaran ManiSingapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.
Li-Jia ChenDepartment of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.
Changwon KeeDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.
David F Garway-HeathNational Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK.
Sarangapani SripriyaSNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Nobuo FuseDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.
Khaled K Abu-AmeroDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA.
Chukai HuangChinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.
Prasanthi NamburiDepartment of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.
Kathryn BurdonMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Department of Ophthalmology, Flinders University, Adelaide, Australia.
Shamira A PereraSingapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.
Puya GharahkhaniDepartment of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Ying LinSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Morio UenoDepartment of Ophthalmology.
Mineo OzakiOzaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066, Japan.
Takanori MizoguchiMizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki 857-0016, Japan.
Subbiah Ramasamy KrishnadasGlaucoma Services, Aravind Eye Hospital, Madurai, Tamilnadu, India.
Essam A OsmanDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mei Chin LeeSingapore Eye Research Institute.
Anita S Y ChanSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Liza-Sharmini A TajudinDepartment of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Tan DoVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Aurelien GoncalvesOphthalmology Department.
Pascal ReynierBiochemistry Department, Angers University Hospital, Angers, France.
Hong ZhangDepartment of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Rupert BourneHuntingdon Glaucoma Diagnostic & Research Centre, Hinchingbrooke Hospital, Huntingdon, UK.
David GohSingapore National Eye Center, Singapore, Singapore.
David BroadwayNorfolk & Norwich University Hospital NHS Trust, Norwich, UK.
Rahat HusainSingapore National Eye Center, Singapore, Singapore.
Anil K NegiHeart of UK NHS Foundation Trust, Birmingham, UK.
Daniel H SuSingapore National Eye Center, Singapore, Singapore.
Ching-Lin HoSingapore National Eye Center, Singapore, Singapore.
Augusto Azuara BlancoSchool of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland, UK.
Christopher K S LeungDepartment of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.
Tina T WongSingapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.
Azhany YakubDepartment of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Yutao LiuDepartment of Medicine, Duke University Medical Center, Durham, NC, USA, Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia.
Monisha E NongpiurSingapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.
Jong Chul HanDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.
Do Nhu HonVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Balekudaru ShanthaMedical Research Foundation, Sankara Nethralaya, Chennai, India.
Bowen ZhaoBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jinghong SangBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
NiHong ZhangBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Ryuichi SatoDepartment of Genomic Medical Sciences.
Kengo YoshiiDepartment of Medical Statistics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Songhomita Panda-JonasDepartment of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
Allison E Ashley KochDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Leon W HerndonDepartment of Ophthalmology, Duke University Eye Center, Durham, NC, USA.
Sayoko E MoroiDepartment of Ophthalmology and Visual Sciences.
Pratap ChallaDepartment of Ophthalmology, Duke University Eye Center, Durham, NC, USA.
Jia Nee FooDivision of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Jin-Xin BeiState Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.
Yi-Xin ZengState Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.
Cameron P SimmonsClinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7LJ, UK.
Tran Nguyen Bich ChauClinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam.
Philomenadin Ferdinamarie SharmilaSNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Merwyn ChewSingapore Eye Research Institute.
Blanche LimSingapore Eye Research Institute.
Pansy O S TamDepartment of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.
Elaine ChuaSingapore Eye Research Institute.
Xiao Yu NgSingapore Eye Research Institute.
Victor H K YongSingapore Eye Research Institute.
Yaan Fun ChongSingapore Eye Research Institute.
Wee Yang MeahDivision of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Saravanan VijayanDepartment of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.
Sohn SeongsooDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.
Wang XuSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Yik Ying TeoDivision of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Jessica N Cooke BaileyDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
Jae H KangChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Jonathan L HainesDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
Ching Yu ChengSingapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.
Seang-Mei SawSingapore Eye Research Institute, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
E-Shyong TaiDepartment of Medicine, National University Health System & National University of Singapore, Singapore.
ICAARE-Glaucoma Consortium
NEIGHBORHOOD Consortium
Julia E RichardsDepartment of Ophthalmology and Visual Sciences, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Robert RitchEinhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY, USA.
Douglas E GaasterlandEye Doctors of Washington DC, Washington, DC, USA.
Louis R PasqualeChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Jianjun LiuDivision of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Jost B JonasDepartment of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
Dan MileaSingapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.
Ronnie GeorgeMedical Research Foundation, Sankara Nethralaya, Chennai, India.
Saleh A Al-ObeidanDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Kazuhiko MoriDepartment of Ophthalmology.
Stuart MacgregorDepartment of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Alex W HewittMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.
Christopher A GirkinDepartment of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.
Mingzhi ZhangChinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.
Periasamy SundaresanDepartment of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.
Lingam VijayaMedical Research Foundation, Sankara Nethralaya, Chennai, India.
David A MackeyMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA, Australia.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine.
Jamie E CraigDepartment of Ophthalmology, Flinders University, Adelaide, Australia.
Xinghuai SunDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China, Myopia Key Laboratory of the Ministry of Health of China, Shanghai, China and.
Shigeru KinoshitaDepartment of Ophthalmology.
Janey L WiggsDepartment of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.
Chiea-Chuen KhorDivision of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.
Zhenglin YangSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chinese Academy of Sciences, Sichuan Translational Medicine Hospital, Chengdu, China.
Chi Pui PangDepartment of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.
Ningli WangBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Michael A HauserDepartment of Ophthalmology, Duke University Eye Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Kei TashiroDepartment of Genomic Medical Sciences.
Tin AungSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.
Eranga N VithanaSingapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.
Singapore Eye Research Institute · SGSingapore National Eye Center · SGGenome Institute of Singapore · SGSankara Nethralaya · INCapital Medical University · CNDuke-NUS Medical School · SGDuke University · USHong Kong Eye Hospital · CNCenter for Genomic Science · ITNational University Health System · SGUniversity of Tasmania · AUBrigham and Women's Hospital · USCase Western Reserve University · USHospital Universiti Sains Malaysia · MYKing Saud University · SAQIMR Berghofer Medical Research Institute · AUShantou University · CNSouthern Medical University · CNSungkyunkwan University · KRUniversity of Alabama at Birmingham · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Structural dynamics of developing auditory circuitsP20RR015574 · NCRR · WEST VIRGINIA UNIVERSITY · PI LEWIS, JAMES W · 2000 to 2009
$18.1M
Novel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5M
P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Eric A Pierce · 2002 to 2026
$15.1M
SNP discoveryP01HL073042 · NHLBI · DUKE UNIVERSITY · PI NEVINS, JOSEPH R · 2002 to 2006
$13.5M
Unifying Genetics Epidemiology of Macular DegenerationR01EY012118 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AGARWAL, ANITA, HAINES, JONATHAN L · 2006 to 2015
$12.2M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Gene-Environment Interactions in GlaucomaR01EY015473 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI PASQUALE, LOUIS ROBERT · 2005 to 2021
$8.3M
NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA001833NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA136725NCI NIH HHS U01 CA049449NCI NIH HHS UM1 CA167552NCRR NIH HHS P20 RR015574NEI NIH HHS P30 EY005722NEI NIH HHS P30 EY014104NEI NIH HHS R01 EY008208NEI NIH HHS R01 EY009580NEI NIH HHS R01 EY009847NEI NIH HHS R01 EY010886NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY011671NEI NIH HHS R01 EY012118NEI NIH HHS R01 EY013178NEI NIH HHS R01 EY013315NEI NIH HHS R01 EY015473NEI NIH HHS R01 EY015543NEI NIH HHS R01 EY015872NEI NIH HHS R01 EY018660NEI NIH HHS R01 EY019126NEI NIH HHS R01 EY022305NEI NIH HHS R01 EY023512NEI NIH HHS R01 EY023646NEI NIH HHS R03 EY015682NEI NIH HHS R56 EY011671NEI NIH HHS T32 EY007157NEI NIH HHS T32 EY021453NEI NIH HHS U10 EY012118NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004608NHGRI NIH HHS U01 HG004728NHLBI NIH HHS P01 HL073042NHLBI NIH HHS R01 HL073389
6 · The paper itself

Abstract

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.

Indexed as

Polymorphism, Single NucleotideAgedAged, 80 and overAllelesFemaleGenetic VariationGenotypeGlaucoma, Open-AngleHumansMaleMiddle AgedProteoglycansReceptors, Transforming Growth Factor betabetaglycanProteoglycansReceptors, Transforming Growth Factor beta

Identifiers

PMID25861811
PMCPMC4459396
OpenAlexW2142283589

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.