ArticleBiological psychiatry2016
Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder.
Article in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts.Biological psychiatry · 2019Pooled it
- Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis.NPJ genomic medicine · 2022Article
- CNVs Associated with Different Clinical Phenotypes of Psoriasis and Anti-TNF-Induced Palmoplantar Pustulosis.Journal of personalized medicine · 2022Article
- Association of Rare Copy Number Variants With Risk of Depression.JAMA psychiatry · 2019Article
- The genetics of neuropsychiatric disorders.Brain and neuroscience advances · 2019Article
- [Breakthrough in understanding the molecular causes of psychiatric disorders].Der Nervenarzt · 2019Review
- Whole genome sequencing in psychiatric disorders: the WGSPD consortium.Nature neuroscience · 2017Review
- Runs of homozygosity, copy number variation, and risk for depression and suicidal behavior in an Arab Bedouin kindred.Psychiatric genetics · 2017Article
- Genomic Disorders in Psychiatry-What Does the Clinician Need to Know?Current psychiatry reports · 2017Review
- Sex chromosome abnormalities and psychiatric diseases.Oncotarget · 2017Review
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
Corrections and comments
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Authors and funding
24 authors at 17 institutions in 8 countries.
Funding
Abstract
backgroundDefining the molecular genomic basis of the likelihood of developing depressive disorder is a considerable challenge. We previously associated rare, exonic deletion copy number variants (CNV) with recurrent depressive disorder (RDD). Sex chromosome abnormalities also have been observed to co-occur with RDD.
methodsIn this reanalysis of our RDD dataset (N = 3106 cases; 459 screened control samples and 2699 population control samples), we further investigated the role of larger CNVs and chromosomal abnormalities in RDD and performed association analyses with clinical data derived from this dataset.
resultsWe found an enrichment of Turner's syndrome among cases of depression compared with the frequency observed in a large population sample (N = 34,910) of live-born infants collected in Denmark (two-sided p = .023, odds ratio = 7.76 [95% confidence interval = 1.79-33.6]), a case of diploid/triploid mosaicism, and several cases of uniparental isodisomy. In contrast to our previous analysis, large deletion CNVs were no more frequent in cases than control samples, although deletion CNVs in cases contained more genes than control samples (two-sided p = .0002).
conclusionsAfter statistical correction for multiple comparisons, our data do not support a substantial role for CNVs in RDD, although (as has been observed in similar samples) occasional cases may harbor large variants with etiological significance. Genetic pleiotropy and sample heterogeneity suggest that very large sample sizes are required to study conclusively the role of genetic variation in mood disorders.
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