ArticleJundishapur journal of microbiology2015
Extracellular enzymes and susceptibility to fluconazole in Candida strains isolated from patients with vaginitis and healthy individuals.
Article in Jundishapur journal of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 23 citations in OpenAlex.
- Biochemical typing and evaluation of pathogenicity in vulvovaginal isolates of Candida albicans complexBiomedica : revista del Instituto Nacional de Salud · 2023Article
- The Interplay betweenMicroorganisms · 2023Review
- Evaluation of Anti-Journal of fungi (Basel, Switzerland) · 2022Article
- ABC typing and extracellular enzyme production of Candida albicans isolated from Candida vulvovaginitis.Journal of clinical laboratory analysis · 2022Article
- Virulence Factors as Promoters of Chronic Vulvovaginal Candidosis: A Review.Mycopathologia · 2021Review
- Candiduria; a review article with specific data from Iran.Turkish journal of urology · 2018Review
- Isolation, molecular identification, and antifungal susceptibility profiles of vaginal isolates ofIranian journal of microbiology · 2016Article
- The Frequency, Antifungal Susceptibility and Enzymatic Profiles ofJundishapur journal of microbiology · 2016Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundExtracellular phospholipase, proteinase, and coagulase are accounted as the major virulence factors in Candida albicans. Several reports showed that the incidence of resistance to fluconazole has risen during last two decades.
objectivesThe present study has investigated the extracellular enzymes of C. albicans and non-albicans species isolated from both patients with vaginitis and healthy women. In addition, susceptibility of the isolates was evaluated against fluconazole. PATIENTS AND
methodsVaginal samples were collected using sterile cotton swabs and inoculated on CHROMagar Candida. Routine morphological tests and ID 32C and API 20C AUX Kits were used to identify species. Phospholipase, proteinase, and coagulase activity were determined by standard methods. Susceptibility to fluconazole was also evaluated using ATB Fungus 3 Kits.
resultsThe phospholipase activity was detected in 66.7% of the tested isolates recovered from patients with vaginitis. In the present study, phospholipase activity with higher Pz values (< 0.70) was more common in patients with vaginitis (28 of 66 isolates) whereas this rate in the normal individual was 13 of 42. Proteinase activity was detected in 74.2% and 61.9% of tested isolates recovered from patients and normal individuals, respectively. All tested isolates were negative for coagulase activity. In the present study, resistance to fluconazole was found in 34.8% of isolates. C. dubliniensis was the most common isolate (6 out of 11 isolates) that showed resistance to fluconazole.
conclusionsOur results showed that C. albicans was the most frequently isolated from both patients with vaginitis and normal individual. In the present study, we could not find any correlation between extracellular activities and sources of isolates (patients and normal flora) and sensitivity or resistance to fluconazole.
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