Evidence map›Paper›PMID 25861414›Full record

ReviewOxidative medicine and cellular longevity2015

Chronic kidney disease influences multiple systems: describing the relationship between oxidative stress, inflammation, kidney damage, and concomitant disease.

Patrick S Tucker, Aaron T Scanlan, Vincent J Dalbo

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 2 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.

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  12. Novel native probiotics with protective effects against nickel-induced kidney injury: a strategy for heavy metal toxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Patrick S TuckerClinical Biochemistry Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia.
Aaron T ScanlanClinical Biochemistry Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia.
Vincent J DalboClinical Biochemistry Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia.
Central Queensland University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is characterized by increased levels of oxidative stress and inflammation. Oxidative stress and inflammation promote renal injury via damage to molecular components of the kidney. Unfortunately, relationships between inflammation and oxidative stress are cyclical in that the inflammatory processes that exist to repair radical-mediated damage may be a source of additional free radicals, resulting in further damage to renal tissue. Oxidative stress and inflammation also have the ability to become systemic, serving to injure tissues distal to the site of original insult. This review describes select mediators in the exacerbatory relationship between oxidative stress, inflammation, and CKD. This review also discusses oxidative stress, inflammation, and CKD as they pertain to the development and progression of common CKD-associated comorbidities. Lastly, the utility of several widely accessible and cost-effective lifestyle interventions and their ability to reduce oxidative stress and inflammation are discussed and recommendations for future research are provided.

Indexed as

InflammationOxidative StressCytokinesHumansKidneyLife StyleOxidoreductasesReactive Oxygen SpeciesRenal Insufficiency, ChronicCytokinesOxidoreductasesReactive Oxygen Species

Identifiers

PMID25861414
PMCPMC4377508
OpenAlexW1991687135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.