ArticleArchives of medical science : AMS2015
Blood pressure control predicts plasma matrix metalloproteinase-9 in diabetes mellitus type II.
Article in Archives of medical science : AMS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Comparison of microcurrent and low level laser therapy on matrix metalloproteinases and tissue inhibitors of metalloproteinases expressions in surgical wound healing.Scientific reports · 2025Trial
- The Effect of Low-Frequency Magnetic Fields with Low Induction and Red LED Light on Keratinocyte Biological Activity-An In Vitro Research Model.International journal of molecular sciences · 2024Article
- Selected matrix metalloproteinases activity and hypertension-mediated organ damage in relation to uric acid serum level.Cardiology journal · 2021Article
- Matrix metalloproteinase-9 and p53 involved in chronic fluorosis induced blood-brain barrier damage and neurocyte changes.Archives of medical science : AMS · 2019Article
- The effect of antihypertensive treatment on arterial stiffness and serum concentration of selected matrix metalloproteinases.Archives of medical science : AMS · 2017Article
- CTGF upregulation correlates with MMP-9 level in airway remodeling in a murine model of asthma.Archives of medical science : AMS · 2017Article
- The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation.Journal of diabetes research · 2016Review
- Association of endothelin-1 and matrix metallopeptidase-9 with metabolic syndrome in middle-aged and older adults.Diabetology & metabolic syndrome · 2015Article
- Myrcene exerts anti-asthmatic activity in neonatal rats via modulating the matrix remodeling.International journal of immunopathology and pharmacologyArticle
- Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia.Journal of Zhejiang University. Science. BArticle
- Inflammation, oxidative stress, matrix metalloproteinases and DNA damage in diabetic polyneuropathy and neuropathic pain.Frontiers in neurologyArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMatrix metalloproteinase-9 (MMP-9) plays an important role in extracellular and vascular remodelling. We aimed therefore to assess the role of blood pressure (BP) control on plasma MMP-9 in relation to the presence of diabetes mellitus (DM) type II. MATERIAL AND
methodsPlasma MMP-9 was measured in 61 patients who were divided into two groups depending on their BP control as follows: 49 patients with uncontrolled arterial hypertension (AH) defined as BP values > 130/80 mm Hg and 12 patients with optimal blood pressure values. Plasma MMP-9 levels were measured with immunoassay at discharge. Group comparisons were made with the independent t-test, Mann-Whitney U-test and χ(2) test where appropriate. The associations of the variables with MMP-9 were investigated with linear regression analyses.
resultsThe diabetics made up 34.4% of the investigated patients. Frequency of DM did not differ between the two BP groups (30.0% vs. 36.6%, p > 0.05). Plasma MMP-9 concentrations differed significantly between the diabetics vs. non-diabetics (median: 1.9 ng/ml, range: 1.0-7.3 vs. 1.4 ng/ml, range: 0.5-4.7, p < 0.05). Stratification across the categories of BP control showed a significant correlation between plasma MMP-9 and DM type II only in the uncontrolled BP group. The significance of that relationship disappeared in the group of patients with optimal BP control.
conclusionsPlasma values of MMP-9 are raised in patients with DM type II. The results revealed the impact of the combination of uncontrolled AH and DM type II on vascular remodelling processes.
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