ArticleCancer cell international2015
Interferon gamma polymorphisms and hepatitis B virus-related liver cirrhosis risk in a Chinese population.
Article in Cancer cell international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- TheFrontiers in immunology · 2023Pooled it
- Gene polymorphisms of inflammatory factors in liver cirrhosis.Frontiers in genetics · 2023Pooled it
- Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis.Medicine · 2016Pooled it
- Host and HBV Interactions and Their Potential Impact on Clinical Outcomes.Pathogens (Basel, Switzerland) · 2023Review
- Association between interferon-gamma (IFN-γ) gene polymorphisms (+874A/T and +2109A/G), and susceptibility to hepatitis B viral infection (HBV).Journal of applied biomedicine · 2022Article
- Achievements and Challenges of Genomics-Assisted Breeding in Forest Trees: From Marker-Assisted Selection to Genome Editing.International journal of molecular sciences · 2021Review
- Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma.Scientific reports · 2020Article
- Interferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Correlation between cortisol levels and concurrent infection for hepatitis B cirrhosis patients and countermeasure analysis.Experimental and therapeutic medicine · 2018Article
- A single nucleotide polymorphism of the interferon-γ gene and susceptibility to hepatitis B virus-related cirrhosis: a randomized controlled trial.International journal of clinical and experimental pathology · 2018Article
- Polymorphism of IFN-γ +874T/A associated with production of IFN-γ affects human papillomavirus susceptibility in rural women from Luohe, Henan, China.OncoTargets and therapy · 2018Article
- Effect of Interferon-γ Polymorphisms on Ankylosing Spondylitis: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Genetic variant in visfatin gene promoter contributes to reduced risk of hepatocellular carcinoma in a Chinese population.Oncotarget · 2016Article
- Article
- MAPK inhibitors modulate Smad2/3/4 complex cyto-nuclear translocation in myofibroblasts via Imp7/8 mediation.Molecular and cellular biochemistry · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies proved that interferon gamma (IFN-γ) gene polymorphisms were associated with the risk of hepatitis B virus (HBV) infection. However, the association between IFN-γ polymorphisms and HBV-related liver cirrhosis (HBV-LC) risk is still unclear.
methodsIFN-γ +874 T/A and +2109G/A genotypes were determined in 126 HBV-LC patients, 129 chronic hepatitis B(CHB) patients, and 173 early HBV infection controls using a sequence-specific primer-polymerase chain reaction and a polymerase chain reaction-restriction fragment length polymorphism, respectively.
resultsSignificant associations were observed between +2109A/G polymorphisms and HBV-LC risk in the co-dominant model (GG vs. AA: OR = 0.321, 95% CI = 0.130-0.793, P = 0.014), the allelic model (OR = 0.565, 95% CI = 0.388-0.825, P = 0.003), the dominant model (OR = 0.551, 95% CI = 0.344-0.883, P = 0.013), and the recessive model (OR = 0.385, 95% CI = 0.159-0.930, P = 0.034). In addition, haplotype analysis indicated that the T(+874)G(+2109) haplotype significantly decreased the HBV-LC risk (OR = 0.106, 95% CI = 0.022-0.502, P = 0.000), and A(+874)A(+2109) haplotype significantly increased the LC risk (OR = 1.485, 95% CI = 1.065-2.070, P = 0.019). No significant associations were observed between IFN-γ +874 T/A polymorphisms and HBV-LC risk, as well as the two single-nucleotide polymorphisms (SNPs) and CHB risk (P > 0.05).
conclusionsOur observations suggested a significant association of IFN-γ polymorphisms with HBV-LC risk in the Chinese population.
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