Evidence map›Paper›PMID 25861158›Full record

Trial reportBehavioural neurology2015

The short-term effects of transcranial direct current stimulation on electroencephalography in children with autism: a randomized crossover controlled trial.

Anuwat Amatachaya, Mark P Jensen, Niramol Patjanasoontorn, Narong Auvichayapat, Chanyut Suphakunpinyo, Suparerk Janjarasjitt, Niran Ngernyam, Benchaporn Aree-uea, Paradee Auvichayapat

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Behavioural neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03947086 (Transcranial Direct Current Stimulation for Cognitive Rehabilitation of Children With Autistic Spectrum Disorders), which is not on this map. Cited by 48 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03947086 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Transcranial Direct Current Stimulation for Cognitive Rehabilitation of Children With Autistic Spectrum Disorders

TypeinterventionalSponsorFederal University of ParaíbaRan2018 to 2019Enrolled16ConditionsAutistic Disorders SpectrumArmsTranscranial Direct Current Stimulation (TDCS)- Active, Transcranial Direct Current Stimulation (TDCS)- Sham, Cognitive Training
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  8. Multisession tDCS combined with intrastimulation training improves emotion recognition in adolescents with autism spectrum disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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  16. The use of noninvasive brain stimulation techniques in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anuwat AmatachayaDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0002-8629-5799
Mark P JensenDepartment of Rehabilitation Medicine, University of Washington, 1959 NE Pacific Street, P.O. Box 356490, Seattle, WA 98195-6490, USA.
Niramol PatjanasoontornDepartment of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Narong AuvichayapatDepartment of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0001-6967-8600
Chanyut SuphakunpinyoDepartment of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0001-6170-0332
Suparerk JanjarasjittDepartment of Electrical and Electronic Engineering, Faculty of Engineering, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.
Niran NgernyamDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0003-1387-9432
Benchaporn Aree-ueaDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Paradee AuvichayapatDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0003-1829-2753

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal synaptic maturation and connectivity are possible etiologies of autism. Previous studies showed significantly less alpha activity in autism than normal children. Therefore, we studied the effects of anodal tDCS on peak alpha frequency (PAF) related to autism treatment evaluation checklist (ATEC). Twenty male children with autism were randomly assigned in a crossover design to receive a single session of both active and sham tDCS stimulation (11 mA) over F3 (left dorsolateral prefrontal cortex). Pre- to postsession changes in a measure of cortical activity impacted by tDCS (PAF) and ATEC were compared between groups. We also examined the associations between pre- and postsession changes in the PAF and ATEC. The results show significant pre- to postsession improvements in two domains of ATEC (social and health/behavior domains) following active tDCS, relative to sham treatment. PAF also significantly increased at the stimulation site, and an increase in PAF was significantly associated with improvements in the two domains of ATEC impacted by tDCS. The findings suggest that a single session of anodal tDCS over the F3 may have clinical benefits in children with autism and that those benefits may be related to an increase in PAF.

Indexed as

Electric Stimulation TherapyTranscranial Direct Current StimulationTranscranial Magnetic StimulationAutistic DisorderChildChild, PreschoolCross-Over StudiesElectroencephalographyHumansMaleNeuropsychological TestsPrefrontal CortexTime FactorsTreatment Outcome

Identifiers

PMID25861158
PMCPMC4377433

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.