ArticleEnvironmental health perspectives2015
Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Airborne contaminant exposure and bone development: a systematic review and meta-analysis.Toxicological sciences : an official journal of the Society of Toxicology · 2026Pooled it
- The Association between Lead and Attention-Deficit/Hyperactivity Disorder: A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- Diets Differently Affect Bone Health: Murine Models.International journal of molecular sciences · 2026Article
- Association between blood lead levels and body composition parameters in middle-aged pre- and postmenopausal women.BMC public health · 2026Article
- Effects of a high-fat diet on gut microbiota and possible implications for bone health in male Wistar rats.Lipids · 2025Article
- Effect of Pb, Cu and Zn on development and Wnt/β-catenin signaling pathway genes expression ofToxicology research · 2024Article
- Article
- Preptin Deficiency Does Not Protect against High-Fat Diet-Induced Metabolic Dysfunction or Bone Loss in Mice.JBMR plus · 2023Article
- Lead exposure exacerbates adverse effects of HFD on metabolic function via disruption of gut microbiome, leading to compromised barrier function and inflammation.European journal of nutrition · 2023Article
- Dietary intervention reprograms bone marrow cellular signaling in obese mice.Frontiers in endocrinology · 2023Article
- Avicularin Attenuates Lead-Induced Impairment of Hepatic Glucose Metabolism by Inhibiting the ER Stress-Mediated Inflammatory Pathway.Nutrients · 2022Article
- Chronic exposure to lead acetate promotes changes in the alveolar bone of rats: microstructural and physical-chemical characterization.Environmental science and pollution research international · 2022Article
- Osteoblastic glucocorticoid signaling exacerbates high-fat-diet- induced bone loss and obesity.Bone research · 2021Article
- Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.International journal of molecular sciences · 2021Review
- The associations between serum trace elements and bone mineral density in children under 3 years of age.Scientific reports · 2021Article
- Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways.Iranian journal of pharmaceutical research : IJPR · 2021Review
- Adipotropic effects of heavy metals and their potential role in obesity.Faculty reviews · 2021Review
- Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Effect of lead on proliferation, oxidative stress and genotoxic damage of 3T3-L1 fibroblasts.Toxicology research · 2020Article
- Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice.Bone · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLead (Pb) exposure and obesity are co-occurring risk factors for decreased bone mass in the young, particularly in low socioeconomic communities.
objectivesThe goal of this study was to determine whether the comorbidities of Pb exposure and high-fat diet-induced obesity amplify skeletal deficits independently associated with each of these risk factors, and to explore associated mechanisms of the observed deficiencies.
methodsFive-week-old male C57BL/6J mice were placed on low-fat (10% kcal, LFD) or high-fat (60% kcal, HFD) diets for 12 weeks. Mice were exposed to lifetime Pb (50 ppm) through drinking water.
resultsHFD was associated with increased body mass and glucose intolerance. Both HFD and Pb increased fasting glucose and serum leptin levels. Pb and HFD each reduced trabecular bone quality and together had a further detrimental effect on these bone parameters. Mechanical bone properties of strength were depressed in Pb-exposed bones, but HFD had no significant effect. Both Pb and HFD altered progenitor cell differentiation, promoting osteoclastogenesis and increasing adipogenesis while suppressing osteoblastogenesis. In support of this lineage shift being mediated through altered Wnt signaling, Pb and non-esterified fatty acids in MC3T3 cells increased in vitro PPAR-γ activity and inhibited β-catenin activity. Combining Pb and non-esterified fatty acids enhanced these effects.
conclusionsPb and HFD produced selective deficits in bone accrual that were associated with alterations in progenitor cell activity that may involve reduced Wnt signaling. This study emphasizes the need to assess toxicants together with other risk factors relevant to human health and disease.
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