ArticleEndocrine2015
Serum albumin is associated with peripheral nerve function in patients with type 2 diabetes.
Article in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Blood Urea Nitrogen to Albumin Ratio is Associated with Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Article
- Higher Body Mass Index Is Related to Severe Chemotherapy-Induced Peripheral Neuropathy in Patients with Ovarian Cancer: A Preliminary Retrospective Study.Journal of clinical medicine · 2025Article
- Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes.World journal of diabetes · 2025Article
- Interpretable machine learning models for detecting peripheral neuropathy and lower extremity arterial disease in diabetics: an analysis of critical shared and unique risk factors.BMC medical informatics and decision making · 2024Article
- Electrochemical Skin Conductance by Sudoscan in Non-Dialysis Chronic Kidney Disease Patients.Journal of clinical medicine · 2023Article
- Article
- Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study.Frontiers in endocrinology · 2023Article
- Association of Elevated Serum Uric Acid with Nerve Conduction Function and Peripheral Neuropathy Stratified by Gender and Age in Type 2 Diabetes Patients.Brain sciences · 2022Article
- Association Between Serum Albumin Levels and Diabetic Peripheral Neuropathy Among Patients with Type 2 Diabetes: Effect Modification of Body Mass Index.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Prediction of Diabetic Sensorimotor Polyneuropathy Using Machine Learning Techniques.Journal of clinical medicine · 2021Article
- Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus.Journal of diabetes investigation · 2021Article
- Serum albumin was negatively associated with diabetic peripheral neuropathy in Chinese population: a cross-sectional study.Diabetology & metabolic syndrome · 2021Article
- Diagnosis of Muscle Fatigue Using Surface Electromyography and Analysis of Associated Factors in Type 2 Diabetic Patients with Neuropathy: A Preliminary Study.International journal of environmental research and public health · 2021Article
- Hemoglobin, Body Mass Index, and Age as Risk Factors for Paclitaxel- and Oxaliplatin-Induced Peripheral Neuropathy.JAMA network open · 2021Article
- Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes.Journal of diabetes research · 2021Article
- Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Prealbumin to fibrinogen ratio is closely associated with diabetic peripheral neuropathy.Endocrine connections · 2020Article
- Serum levels of homocysteine and circulating antioxidants associated with heart rate variability in patients with unstable angina pectoris.Chinese medical journal · 2019Article
- Low serum magnesium levels are associated with impaired peripheral nerve function in type 2 diabetic patients.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to investigate the association between serum albumin concentrations and nerve conduction (NC) parameters in Chinese patients with type 2 diabetes (T2DM). A total of 409 T2DM patients were enrolled between October 2010 and April 2014. All participants underwent nerve conduction studies. The composite Z scores for NC parameters including conduction velocity (CV), amplitude, and latency were calculated as well. Serum albumin was measured by Bromcresol Green dye-binding method. The composite Z scores of CV and amplitude increased with the increasing albumin tertiles (test for trend, both P < 0.001), while the composite Z score of latency decreased with increasing albumin tertiles (test for trend, P < 0.001). After adjusting for age, sex, duration, and HbA1c, higher serum albumin concentrations were associated with higher composite Z scores of CV (β = 0.314, P < 0.001), amplitude (β = 0.279, P < 0.001), and lower composite Z score of latency (β = -0.279, P < 0.001). When participants were stratified into albuminuria and normoalbuminuria group, we found the associations of serum albumin with composite Z scores of NC parameters remained significant only in the albuminuria group (CV Z score: β = 0.253, P = 0.002; amplitude Z score: β = 0.233, P = 0.006; latency Z score: β = -0.217 P = 0.013) after further adjustment for urinary albumin to creatinine ratio. The optimal cutoff point of serum albumin to indicate abnormal peripheral nerve function was 36.75 g/L in T2DM patients with albuminuria, with a sensitivity of 65.6 % and a specificity of 78.0 %. Serum albumin was independently associated with peripheral nerve function in T2DM patients, especially in those with albuminuria. Serum albumin could be a potential biomarker for diabetic peripheral neuropathy.
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