ArticlePloS one2015
Effective population size, extended linkage disequilibrium and signatures of selection in the rare dog breed lundehund.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- An analysis of the genomic architecture of the worldwide Irish Wolfhound dogs.Scientific reports · 2026Article
- Genetic diversity and population structure of the Taigan dog breed.FEBS open bio · 2025Article
- Genetic diversity and origin of Kazakh Tobet Dogs.Scientific reports · 2024Article
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- Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture.Genome biology · 2023Article
- Identification of Genomic Signatures in Bullmastiff Dogs Using Composite Selection Signals Analysis of 23 Purebred Clades.Animals : an open access journal from MDPI · 2023Article
- Genetic Diversity and Trends of Ancestral and New Inbreeding in Deutsch Drahthaar Assessed by Pedigree Data.Animals : an open access journal from MDPI · 2022Article
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- Linkage Disequilibrium and Effective Population Size of Buffalo Populations of Iran, Turkey, Pakistan, and Egypt Using a Medium Density SNP Array.Frontiers in genetics · 2021Article
- Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits.Advanced genetics (Hoboken, N.J.) · 2020Article
- Genetic Variability in Polish Lowland Sheepdogs Assessed by Pedigree and Genomic Data.Animals : an open access journal from MDPI · 2020Article
- The German Shorthair Pointer Dog Breed (Animals : an open access journal from MDPI · 2020Article
- Demographic assessment of the Dalmatian dog - effective population size, linkage disequilibrium and inbreeding coefficients.Canine medicine and genetics · 2020Article
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- Studies of modern Italian dog populations reveal multiple patterns for domestic breed evolution.Ecology and evolution · 2018Article
- Genomic data illuminates demography, genetic structure and selection of a popular dog breed.BMC genomics · 2017Article
- Article
- Cross-Breeding Is Inevitable to Conserve the Highly Inbred Population of Puffin Hunter: The Norwegian Lundehund.PloS one · 2017Article
- Variant detection and runs of homozygosity in next generation sequencing data elucidate the genetic background of Lundehund syndrome.BMC genomics · 2016Article
- Runs of homozygosity reveal signatures of positive selection for reproduction traits in breed and non-breed horses.BMC genomics · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Lundehund is an old dog breed with remarkable anatomical features including polydactyly in all four limbs and extraordinary flexibility of the spine. We genotyped 28 Lundehund using the canine Illumina high density beadchip to estimate the effective population size (Ne) and inbreeding coefficients as well as to identify potential regions of positive selection. The decay of linkage disequilibrium was slow with r2 = 0.95 in 50 kb distance. The last 7-200 generations ago, Ne was at 10-13. An increase of Ne was noted in the very recent generations with a peak value of 19 for Ne at generation 4. The FROH estimated for 50-, 65- and 358-SNP windows were 0.87, 087 and 0.81, respectively. The most likely estimates for FROH after removing identical-by-state segments due to linkage disequilibria were at 0.80-0.81. The extreme loss of heterozygosity has been accumulated through continued inbreeding over 200 generations within a probably closed population with a small effective population size. The mean inbreeding coefficient based on pedigree data for the last 11 generations (FPed = 0.10) was strongly biased downwards due to the unknown coancestry of the founders in this pedigree data. The long-range haplotype test identified regions with genes involved in processes of immunity, olfaction, woundhealing and neuronal development as potential targets of selection. The genes QSOX2, BMPR1B and PRRX2 as well as MYOM1 are candidates for selection on the Lundehund characteristics small body size, increased number of digits per paw and extraordinary mobility, respectively.
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