SynthesisPloS one2015
An individual patient data meta-analysis on characteristics, treatments and outcomes of glioblastoma/ gliosarcoma patients with metastases outside of the central nervous system.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bone metastasis from glioblastoma: a systematic review.Journal of neuro-oncology · 2022Pooled it
- Pooled it
- Prognostic nomogram for glioblastoma (GBM) patients presenting with distant extension: a seer-based study.Journal of cancer research and clinical oncology · 2023Trial
- Extracranial Metastases in Glioblastoma, IDH-Wildtype: A Case Series.Diagnostics (Basel, Switzerland) · 2026Article
- Rapidly progressive scalp and lung metastases with fatal pneumothorax in glioblastoma, IDH-wildtype, with MET and CDK6 amplifications: a case report of clinical course and postmortem autopsy, including genetic analysis.Brain tumor pathology · 2025Article
- Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis.BJC reports · 2025Article
- Late spinal metastasis of glioblastoma multiforme after maximal tumor resection: A case report.Surgical neurology international · 2025Article
- Metastatic extraneural glioblastoma diagnosed with molecular testing.The oncologist · 2024Article
- Spinal and cervical nodal metastases in a patient with glioblastoma.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- Metastatic glioblastoma to the lungs: a case report and literature review.CNS oncology · 2024Review
- Article
- Breaking boundaries: A rare case of glioblastoma with uncommon extraneural metastases: A case report and literature review.Brain & spine · 2024Article
- The prognostic significance of synchronous metastasis in glioblastoma multiforme patients: a propensity score-matched analysis using SEER data.Frontiers in neurology · 2024Article
- Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.Cancer reports (Hoboken, N.J.) · 2023Review
- Systemic Metastasis of Pediatric Diffuse High-grade Astrocytoma: A Case Report.NMC case report journal · 2023Article
- Rapid progression of subcutaneous glioblastoma: A case report and literature review.Frontiers in oncology · 2023Article
- A Case of Extracranial Metastasis of Glioblastoma Multiforme Seen on Bone Scintigraphy.Molecular imaging and radionuclide therapy · 2022Article
- A Case of Glioblastoma, Isocitrate Dehydrogenase Wild Type, With Widely Disseminated Osseous Metastasis.Cureus · 2022Article
- Extracranial metastasis of glioblastoma with genomic analysis: a case report and review of the literature.Translational cancer research · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the characteristics, treatments and outcomes of patients with glioblastoma multiforme (GBM) or gliosarcoma (GS) and metastases outside of the central nervous system (CNS).
methodsPubMed and Web of Science searches for peer-reviewed articles pertaining to GBM/ GS patients with metastatic dissemination were conducted using the keywords gliosarcoma, glioblastoma, GBM, metastasis, metastases and metastatic. Additionally, we performed hand search following the references from the selected papers. Cases with metastases to the CNS were excluded and evaluated in a separate study.
results109 articles published between 1928 and 2013 were eligible. They reported on 150 patients. We observed a remarkable increase in the number of cases per decade over time. Median overall survival from diagnosis of metastasis (OSM+) was 6.0 ± 0.8 months and median overall survival from initial diagnosis (OSID) 13 ± 2.4 months. On univariate analyses, gender, age, the histological subtype, the time interval between initial diagnosis and diagnosis of metastasis and pulmonary involvement did not influence OSM+. We did not observe any substantial treatment progress. A comparison of the present cohort with 84 GBM/ GS patients with exclusive CNS dissemination suggests that metastases outside the CNS are related to a slightly more favorable outcome.
conclusionsThe occurrence of extra-CNS metastasis from GBM/ GS is associated with a dismal prognosis, however it seems to compare slightly favorable to CNS dissemination. Crucial treatment progress has not been achieved over recent decades. A central registry should be considered to consecutively gain more information about the ideal therapeutic approach.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.