Evidence map›Paper›PMID 25860661›Full record

ReviewHuman gene therapy2015

Adoptive T-cell therapy for cancer in the United kingdom: a review of activity for the British Society of Gene and Cell Therapy annual meeting 2015.

David Edward Gilham, John Anderson, John Stephen Bridgeman, Robert Edward Hawkins, Mark Adrian Exley, Hans Stauss, John Maher, Martin Pule, Andrew Kelvin Sewell, Gavin Bendle and 4 more

Abstract readReview
In one paragraph

Review in Human gene therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. [PD-1 expression, mRNA level and cytotoxicity changes in CD19CAR-T cells].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2019
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

David Edward Gilham1Clinical and Experimental Immunotherapy Group, Institute of Cancer Sciences, The University of Manchester, Manchester M20 4BX, United Kingdom.
John Anderson2UCL Institute of Child Health, London WC1N 1EH, United Kingdom.
John Stephen Bridgeman3Cellular Therapeutics Ltd., UMIC Bio-incubator, Manchester M13 9XX, United Kingdom.
Robert Edward Hawkins1Clinical and Experimental Immunotherapy Group, Institute of Cancer Sciences, The University of Manchester, Manchester M20 4BX, United Kingdom.
Mark Adrian Exley4MCCIR, Faculty of Medicine, The University of Manchester, Manchester M13 9NT, United Kingdom.
Hans Stauss5Department of Immunology, University College London, Royal Free Hospital, London NW3 2PF, United Kingdom.
John Maher6Department of Research Oncology, Bermondsey Wing, Guy's Hospital, London SE1 9RT, United Kingdom.
Martin Pule7Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, United Kingdom.
Andrew Kelvin Sewell8Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital, Cardiff CF14 4XN, United Kingdom.
Gavin Bendle9School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Steven Lee9School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Waseem Qasim10Molecular and Cellular Immunology Institute, Institute of Child Health, London WC1N 1EH, United Kingdom.
Adrian Thrasher10Molecular and Cellular Immunology Institute, Institute of Child Health, London WC1N 1EH, United Kingdom.
Emma Morris5Department of Immunology, University College London, Royal Free Hospital, London NW3 2PF, United Kingdom.

Funding

Cancer Research UK 14779Cancer Research UK 15152Department of Health RP-2014-05-007Medical Research Council G0902209Medical Research Council MR/K500732/1Medical Research Council TS/J003530/1Wellcome Trust 100327
6 · The paper itself

Abstract

Adoptive T-cell therapy is delivering objective clinical responses across a number of cancer indications in the early phase clinical setting. Much of this clinical activity is taking place at major clinical academic centers across the United States. This review focuses upon cancer-focused cell therapy activity within the United Kingdom as a contribution to the 2015 British Society of Gene and Cell Therapy annual general meeting. This overview reflects the diversity and expansion of clinical and preclinical studies within the United Kingdom while considering the background context of this work against new infrastructural developments and the requirements of nationalized healthcare delivery within the UK National Health Service.

Indexed as

Immunotherapy, AdoptiveAnimalsBiotechnologyCell- and Tissue-Based TherapyClinical Trials as TopicDrug Evaluation, PreclinicalHumansNeoplasmsT-LymphocytesUnited Kingdom

Identifiers

PMID25860661
PMCPMC4442586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.