ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2015
Hippocampal BDNF content in response to short- and long-term exercise.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions.Molecular biology reports · 2025Pooled it
- The underlying mechanism of physical exercise on neurodegenerative diseases: the mediating role of psychological stress and resilience: a systematic review.Frontiers in psychology · 2025Pooled it
- Article
- The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review.International journal of molecular sciences · 2021Review
- Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats.International journal of environmental research and public health · 2021Article
- Sex differences in the association of photoperiod with hippocampal subfield volumes in older adults: A cross-sectional study in the UK Biobank cohort.Brain and behavior · 2020Article
- Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice.Frontiers in cellular neuroscience · 2020Article
- Voluntary physical exercise protects against behavioral and endocrine reactivity to social and environmental stressors in the prairie vole.Social neuroscience · 2018Article
- Effects of Environmental Enrichment on Doublecortin and BDNF Expression along the Dorso-Ventral Axis of the Dentate Gyrus.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus is a region in the brain that is crucial for learning and memory. Previous researches proved that brain-derived neurotrophic factor (BDNF) is a probable responsible protein in the learning and memory formation process. BDNF content is thought to be affected by environmental enrichment and physical activity. The purpose of this research was to identify the effect of short- and long-term forced exercise on hippocampal BDNF levels. A total of 30 Wistar rats were randomly divided into three groups (control, short-term exercise and long-term exercise) and treated by treadmill running based on their group. As the treadmill running period finished, the animals were anesthetized. The hippocampus was dissected out immediately and BDNF content of the samples was assessed by ELISA. None of the exercise paradigms did make any significant change on hippocampal BDNF levels. Although exercise was proposed to up-regulate BDNF levels, these results show that the intensity or the duration of running paradigm used in forced exercise protocols here was not enough to affect BDNF levels in the hippocampus significantly.
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Registered trials
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