ArticlePloS one2015
Genome-wide methylation patterns in Salmonella enterica Subsp. enterica Serovars.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
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- Biology of host-dependent restriction-modification in prokaryotes.EcoSal Plus · 2025Review
- Integration of themBio · 2022Article
- Changes in the genomes and methylomes of threeFrontiers in microbiology · 2022Article
- Genome archaeology of two laboratory Salmonella enterica enterica sv Typhimurium.G3 (Bethesda, Md.) · 2021Article
- Methylation analysis of Klebsiella pneumoniae from Portuguese hospitals.Scientific reports · 2021Article
- Complete Annotated Genome Sequence of the Salmonella enterica Serovar Typhimurium LT7 Strain STK003, Historically Used in Gene Transfer Studies.Microbiology resource announcements · 2021Article
- Comparative genome analysis of Salmonella enterica serovar Gallinarum biovars Pullorum and Gallinarum decodes strain specific genes.PloS one · 2021Article
- A Single Nucleotide Polymorphism inFrontiers in microbiology · 2021Article
- Genome Sequence, Assembly, and Characterization of the Antagonistic YeastFrontiers in microbiology · 2020Article
- Deciphering bacterial epigenomes using modern sequencing technologies.Nature reviews. Genetics · 2019Review
- Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome.Nucleic acids research · 2018Article
- Comparative genomics of Salmonella enterica serovar Montevideo reveals lineage-specific gene differences that may influence ecological niche association.Microbial genomics · 2018Article
- GenomeTrakr proficiency testing for foodborne pathogen surveillance: an exercise from 2015.Microbial genomics · 2018Article
- Comparative genomics of cocci-shaped Sporosarcina strains with diverse spatial isolation.BMC genomics · 2018Article
- Genes affecting progression of bacteriophage P22 infection in Salmonella identified by transposon and single gene deletion screens.Molecular microbiology · 2018Article
- Genome Sequence, Assembly and Characterization of TwoFrontiers in microbiology · 2018Article
- Genomic sequencing of Neisseria gonorrhoeae to respond to the urgent threat of antimicrobial-resistant gonorrhea.Pathogens and disease · 2017Review
- Identification of amBio · 2017Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
The methylation of DNA bases plays an important role in numerous biological processes including development, gene expression, and DNA replication. Salmonella is an important foodborne pathogen, and methylation in Salmonella is implicated in virulence. Using single molecule real-time (SMRT) DNA-sequencing, we sequenced and assembled the complete genomes of eleven Salmonella enterica isolates from nine different serovars, and analysed the whole-genome methylation patterns of each genome. We describe 16 distinct N6-methyladenine (m6A) methylated motifs, one N4-methylcytosine (m4C) motif, and one combined m6A-m4C motif. Eight of these motifs are novel, i.e., they have not been previously described. We also identified the methyltransferases (MTases) associated with 13 of the motifs. Some motifs are conserved across all Salmonella serovars tested, while others were found only in a subset of serovars. Eight of the nine serovars contained a unique methylated motif that was not found in any other serovar (most of these motifs were part of Type I restriction modification systems), indicating the high diversity of methylation patterns present in Salmonella.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.