Evidence map›Paper›PMID 25860228›Full record

ArticlePloS one2015

Genetic basis of a cognitive complexity metric.

Narelle K Hansell, Graeme S Halford, Glenda Andrews, David H K Shum, Sarah E Harris, Gail Davies, Sanja Franic, Andrea Christoforou, Brendan Zietsch, Jodie Painter and 15 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  5. Article
  6. Review
  7. Article
  8. Review
  9. Transcriptomic context ofProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  10. Article
  11. Article
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  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Narelle K HansellNeuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Graeme S HalfordSchool of Applied Psychology, Griffith University, Mt Gravatt Campus, Brisbane, Australia; Behavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia.
Glenda AndrewsSchool of Applied Psychology, Griffith University, Gold Coast Campus, Southport, Australia; Behavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia.
David H K ShumBehavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Gail DaviesCentre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Sanja FranicDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Andrea ChristoforouK.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Brendan ZietschGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Psychology, University of Queensland, St Lucia, Brisbane, Australia.
Jodie PainterMolecular Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sarah E MedlandQuantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Erik A EhliAvera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, United States of America.
Gareth E DaviesAvera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, United States of America.
Vidar M SteenK.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Astri J LundervoldK.G. Jebsen Center for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Center for Research on Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway.
Ivar ReinvangDepartment of Psychology, University of Oslo, Oslo, Norway.
Grant W MontgomeryMolecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo, Norway; Norwegian Center for Mental Disorders Research (NORMENT) and the K.G. Jebsen Center for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Hilleke E Hulshoff PolBrain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
John M StarrDepartment of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Stephanie Le HellardK.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Margaret J WrightNeuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Genomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M
Collaborative Study of Genetics of Dizygotic TwinningR01HD042157 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI MONTGOMERY, GRANT W · 2002 to 2006
$2.0M
Major Depression: Stage 1 Genomewide Association in Population-Based SamplesR01MH081802 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2007 to 2007
$138k
Biotechnology and Biological Sciences Research Council BB/C514623/1Biotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council G0700704Medical Research Council MC_PC_15018Medical Research Council MR/K026992/1NICHD NIH HHS R01 HD042157NICHD NIH HHS R01 HD042157-01A1NIMH NIH HHS 1RC2 MH089951NIMH NIH HHS 1RC2 MH089995NIMH NIH HHS MH081802NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U24 MH068457NIMH NIH HHS U24 MH068457-06Wellcome Trust 092731Wellcome Trust 102215
6 · The paper itself

Abstract

Relational complexity (RC) is a metric reflecting capacity limitation in relational processing. It plays a crucial role in higher cognitive processes and is an endophenotype for several disorders. However, the genetic underpinnings of complex relational processing have not been investigated. Using the classical twin model, we estimated the heritability of RC and genetic overlap with intelligence (IQ), reasoning, and working memory in a twin and sibling sample aged 15-29 years (N = 787). Further, in an exploratory search for genetic loci contributing to RC, we examined associated genetic markers and genes in our Discovery sample and selected loci for replication in four independent samples (ALSPAC, LBC1936, NTR, NCNG), followed by meta-analysis (N>6500) at the single marker level. Twin modelling showed RC is highly heritable (67%), has considerable genetic overlap with IQ (59%), and is a major component of genetic covariation between reasoning and working memory (72%). At the molecular level, we found preliminary support for four single-marker loci (one in the gene DGKB), and at a gene-based level for the NPS gene, having influence on cognition. These results indicate that genetic sources influencing relational processing are a key component of the genetic architecture of broader cognitive abilities. Further, they suggest a genetic cascade, whereby genetic factors influencing capacity limitation in relational processing have a flow-on effect to more complex cognitive traits, including reasoning and working memory, and ultimately, IQ.

Indexed as

CognitionGenetic Association StudiesAdolescentAdultFemaleGenome-Wide Association StudyHumansMaleMeta-Analysis as TopicModels, BiologicalPolymorphism, Single NucleotideQuantitative Trait, HeritableTwinsYoung Adult

Identifiers

PMID25860228
PMCPMC4393228

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