ArticleCritical care medicine2015
Transfusion of Old RBCs Induces Neuroinflammation and Cognitive Impairment.
Article in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Dexmedetomidine reduces the incidence of postoperative delirium after cardiac surgery: a meta-analysis of randomized controlled trials.BMC anesthesiology · 2021Pooled it
- Postoperative Delerium Associated with Autologous vs Allogeneic Blood Transfusion in Elderly Hip Arthroplasty Patients Undergoing Combined Spinal-Epidural Anesthesia: A Single-Center Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Intravenous Tranexamic Acid Reduces the Incidence of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: A Retrospective Cohort Study.Drug design, development and therapy · 2026Article
- Time-Dependent Changes in Malondialdehyde and Free-Hemoglobin in Leukoreduced and Non-Leukoreduced Canine Packed Red Blood Cells Units During Storage.Veterinary sciences · 2025Article
- Cognitive dysfunction, psychiatric distress, and functional decline after liver transplantation.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025Article
- Exploring Infantile Epileptic Spasm Syndrome: A Proteomic Analysis of Plasma Using the Data-Independent Acquisition Approach.Journal of proteome research · 2024Article
- Unplanned emergency department visits within 90 days of hip hemiarthroplasty for osteoporotic femoral neck fractures: Reasons, risks, and mortalities.Osteoporosis and sarcopenia · 2024Article
- Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway.Cell communication and signaling : CCS · 2024Article
- Vicious cycle of oxidative stress and neuroinflammation in pathophysiology of chronic vascular encephalopathy.Frontiers in physiology · 2024Review
- The Impact of Blood Transfusion in Developing Postoperative Delirium in Patients with Hip Fracture Surgery.Journal of clinical medicine · 2023Article
- Utility of Screening for Cognitive Impairment at Hospital Discharge in Adult Survivors of Critical Illness.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2022Article
- Heterogeneous nuclear ribonucleoprotein A2/B1 as a novel biomarker in elderly patients for the prediction of postoperative neurocognitive dysfunction: A prospective nested case-control study.Frontiers in aging neuroscience · 2022Article
- Red Blood Cell Transfusion and Postoperative Delirium in Hip Fracture Surgery Patients: A Retrospective Observational Cohort Study.Anesthesiology research and practice · 2021Article
- Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors.Molecular medicine reports · 2021Article
- Donor-dependent aging of young and old red blood cell subpopulations: Metabolic and functional heterogeneity.Transfusion · 2020Article
- Attenuation of noisy environment-induced neuroinflammation and dysfunction of learning and memory by minocycline during perioperative period in mice.Brain research bulletin · 2020Article
- Observational
- Ginsenoside Rg1 attenuates isoflurane/surgery-induced cognitive disorders and sirtuin 3 dysfunction.Bioscience reports · 2019Article
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly.Frontiers in aging neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTransfusing RBCs stored for longer than 14 days (old RBC) in humans is common. This transfusion can injure organs, such as lungs and kidneys. We determined whether transfusion with old RBC injured brain.
designProspective, controlled animal study.
settingUniversity research laboratory. SUBJECTS: Adult male Sprague-Dawley rats.
interventionsSix-month-old Sprague-Dawley rats lost 20% total blood volume and then received RBC prepared from equal volume of the lost blood. RBC was stored for 1 day (fresh RBC) or 7 days (old RBC, storage lesions similar to those of human RBC stored for 28 d). Some rats received IV cell-free hemoglobin. These rats were not subjected to hemorrhage and RBC transfusion. MEASUREMENTS AND MAIN
resultsRats were subjected to Barnes maze and fear conditioning tests from 1 week after blood transfusion. Rats transfused with old RBC but not fresh RBC took a longer time to identify the target hole in the Barnes maze and had less context-related fear conditioning behavior than control rats. Old RBC significantly increased interleukin 6 and ionized calcium-binding adapter molecule 1 in the hippocampus at 24 hours after the transfusion. These effects were attenuated by sulforaphane and minocycline, an antibiotic with anti-inflammatory property. Old RBC solution had a higher concentration of cell-free hemoglobin. Sulforaphane increased haptoglobin, a chelator of cell-free hemoglobin. Rats that received cell-free hemoglobin had a pattern of neuroinflammation and impairment of learning and memory similar to that of rats that received old RBC.
conclusionsThese results provide initial evidence to suggest that transfusion of old RBC induces neuroinflammation and impairment of learning and memory. These effects may be mediated by cell-free hemoglobin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.