ArticleJournal of the American Chemical Society2015
Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A simplified, robust protocol for [Scientific reports · 2025Article
- Sultones for Radiofluorination and Bioconjugation: Fluorine-18 Labeling of Native Proteins and Glycoproteins.ACS omega · 2025Article
- [Molecules (Basel, Switzerland) · 2023Article
- State of the art procedures towards reactive [EJNMMI radiopharmacy and chemistry · 2023Review
- Organomediated cleavage of benzoyl group enables an efficient synthesis of 1-(6-nitropyridin-2-yl)thiourea and its application for developingBioorganic chemistry · 2022Article
- Recent Advances in Synthetic Methodologies to Form C-Frontiers in chemistry · 2022Review
- Closing the gap betweenEJNMMI radiopharmacy and chemistry · 2021Review
- Synthesis and biological evaluation of PET tracers designed for imaging of calcium activated potassium channel 3.1 (KRSC advances · 2021Article
- The Non-Anhydrous, Minimally Basic Synthesis of the Dopamine DChemistry (Basel, Switzerland) · 2021Article
- Sulfur [Journal of the American Chemical Society · 2021Article
- A non-anhydrous, minimally basic protocol for the simplification of nucleophilicScientific reports · 2020Article
- An azeotropic drying-free approach for copper-mediated radiofluorination without addition of base.Journal of labelled compounds & radiopharmaceuticals · 2019Article
- Chemistry for Positron Emission Tomography: Recent Advances inAngewandte Chemie (International ed. in English) · 2019Review
- Performing multi-step chemical reactions in microliter-sized droplets by leveraging a simple passive transport mechanism.Lab on a chip · 2017Article
- An automated synthesizer for electrochemicalApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2017Article
- Development of Customized [Scientific reports · 2017Article
- Sulfur - fluorine bond in PET radiochemistry.EJNMMI radiopharmacy and chemistry · 2017Review
- Facile room temperature synthesis of fluorine-18 labeled fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester without azeotropic drying of fluorine-18.Nuclear medicine and biology · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
Nucleophilic radiofluorination is an efficient synthetic route to many positron-emission tomography (PET) probes, but removal of water to activate the cyclotron-produced [(18)F]fluoride has to be performed prior to reaction, which significantly increases overall radiolabeling time and causes radioactivity loss. In this report, we demonstrate the possibility of (18)F-radiofluorination in highly aqueous medium. The method utilizes titania nanoparticles, 1:1 (v/v) acetonitrile-thexyl alcohol solvent mixture, and tetra-n-butylammonium bicarbonate as a phase-transfer agent. Efficient radiolabeling is directly performed with aqueous [(18)F]fluoride without the need for a drying/azeotroping step to significantly reduce radiosynthesis time. High radiochemical purity of the target compound is also achieved. The substrate scope of the synthetic strategy is demonstrated with a range of aromatic, aliphatic, and cycloaliphatic tosylated precursors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.