ArticleJournal of neuro-oncology2015
Proton therapy for atypical meningiomas.
Article in Journal of neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Effectiveness and safety of proton therapy in intracranial meningioma treatment: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Proton beam therapy indications in the Kingdom of Saudi Arabia: A SARO clinical practice guideline.Saudi medical journal · 2025Guideline
- Prospective, Randomized Study of Radiation Dose Escalation With Combined Proton-Photon Therapy for Benign Meningiomas.International journal of radiation oncology, biology, physics · 2017Trial
- Proton therapy for intracranial meningioma: a single-institution retrospective analysis of efficacy, survival and toxicity outcomes.Journal of neuro-oncology · 2024Article
- Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors.Neuro-oncology practice · 2024Review
- Radiotherapy intensification for atypical and malignant meningiomas: A systematic review.Neuro-oncology practice · 2024Review
- How proton therapy fits into the management of adult intracranial tumors.Neuro-oncology · 2024Review
- Adjuvant proton beam therapy in patients with grade 2 meningiomas.Surgical neurology international · 2024Article
- Particle beam radiotherapy in the treatment of WHO grade 2 and 3 meningiomas: an early experience from Shanghai Proton and Heavy Ion Center.Journal of neuro-oncology · 2023Article
- Long Term Outcome and Quality of Life of Intracranial Meningioma Patients Treated with Pencil Beam Scanning Proton Therapy.Cancers · 2023Article
- Dose-response relationship in patients with newly diagnosed atypical meningioma treated with adjuvant radiotherapy.Journal of neuro-oncology · 2023Article
- Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma.Scientific reports · 2022Article
- Predict Treatment Response by Magnetic Resonance Diffusion Weighted Imaging: A Preliminary Study on 46 Meningiomas Treated with Proton-Therapy.Diagnostics (Basel, Switzerland) · 2021Article
- Outcomes of salvage radiation for recurrent world health organization grade II meningiomas: a retrospective cohort study.Journal of neuro-oncology · 2021Article
- Particle therapy in the future of precision therapy.The British journal of radiology · 2020Review
- Proton therapy for brain tumours in the area of evidence-based medicine.The British journal of radiology · 2020Review
- Proton Therapy for Intracranial Meningioma for the Treatment of Primary/Recurrent Disease Including Re-Irradiation.Frontiers in oncology · 2020Review
- Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia.Saudi medical journal · 2019Article
- Proton beam therapy for cancer in the era of precision medicine.Journal of hematology & oncology · 2018Review
- Clinical outcome after particle therapy for meningiomas of the skull base: toxicity and local control in patients treated with active rasterscanning.Radiation oncology (London, England) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report clinical outcomes of proton therapy in patients with World Health Organization grade 2 (atypical) meningiomas. Between 2005 and 2013, 22 patients with atypical meningiomas were treated to a median dose of 63 Gy (RBE) using proton therapy, as an adjuvant therapy after surgery (n = 12) or for recurrence or progression of residual tumor (n = 10). Six patients had presumed radiation-induced meningiomas, but none had received prior radiotherapy for their meningioma. The median follow-up time after radiation was 39 months (range 7-104) and all patients remain alive at last follow-up. The 5-year estimate of local control was 71.1% (95% CI 49.3-92.9%). The 5-year estimate of local control was 87.5% following a radiation dose >60 Gy (RBE), compared to 50.0% for ≤ 60 Gy (RBE) (p = 0.038). The 5-year estimate of neuraxis dissemination was 5% (95% CI 0-14.6%) and 6.2% (95% CI 0-18.2%) for metastases outside of the central nervous system. Radiation necrosis was observed in one patient with a history of prior cranial irradiation. Fractionated proton therapy was associated with favorable tumor control rates for grade 2 meningiomas. Prospective studies are needed to define the optimal radiation dose for high-grade meningiomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.