ArticleMolecules (Basel, Switzerland)2015
Biological activities and cytotoxicity of diterpenes from Copaifera spp. Oleoresins.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 76 citations in OpenAlex.
- Exploring Copaiba and Andiroba Oils: A Comprehensive Review of Composition, Physicochemical Properties and Pharmacological Activities in Advanced Delivery Systems.Pharmaceutics · 2026Review
- Chemical Profiling and Biological Activity of Copaiba Oil-Resin Samples and Development of HPLC-DAD Method for the Analysis of β-Caryophyllene.Biomedical chromatography : BMC · 2026Article
- Essential Oils as Natural Defenders: Exploring Their Antioxidant and Antimicrobial Potential Against Multidrug-Resistant (MDR) Bacteria.International journal of microbiology · 2026Article
- Diterpenes: Nature's Hidden Gems of Immunomodulation.International journal of molecular sciences · 2025Review
- Liquid Chromatography Quadrupole Time-of-Flight Tandem Mass Spectrometry Characterization of Ethyl Acetate Fraction fromInternational journal of molecular sciences · 2025Article
- Solid Lipid Nanoparticles Based on Babassu Oil and Copaiba Oleoresin: A Promising Approach for Prostate Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2024Article
- The amide derivative of anticopalic acid induces non-apoptotic cell death in triple-negative breast cancer cells by inhibiting FAK activation.Scientific reports · 2023Article
- Toxicological Effects of Copaiba Oil (Plants (Basel, Switzerland) · 2023Review
- Kaurenoic Acid Reduces Ongoing Chronic Constriction Injury-Induced Neuropathic Pain: Nitric Oxide Silencing of Dorsal Root Ganglia Neurons.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Green Synthesis of Endolichenic Fungi Functionalized Silver Nanoparticles: The Role in Antimicrobial, Anti-Cancer, and Mosquitocidal Activities.International journal of molecular sciences · 2022Article
- Synthesis of salicylic acid phenylethyl ester (SAPE) and its implication in immunomodulatory and anticancer roles.Scientific reports · 2022Article
- Anti-Inflammatory Potential of the Oleoresin from the Amazonian TreeVeterinary sciences · 2021Article
- Exploring the Phytochemicals ofPlants (Basel, Switzerland) · 2021Article
- UHPLC-HRMS/MS on untargeted metabolomics: a case study withRSC advances · 2021Article
- Hydrogel Containing Oleoresin FromFrontiers in microbiology · 2019Article
- Effects of copaiba oil on dermonecrosis induced byThe journal of venomous animals and toxins including tropical diseases · 2019Article
- An Overview of Biotransformation and Toxicity of Diterpenes.Molecules (Basel, Switzerland) · 2018Review
- Review
- Copaiba oil influences ventral hernia repair with Vicryl® mesh?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgeryArticle
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copaifera spp. are Amazonian species widely studied and whose oleoresins are used by local people for various medicinal purposes. However, a detailed study of the activity of the main phytochemical components of these oleoresins remains to be done. Here, we studied the cytotoxicity and in vitro anti-inflammatory effects of six diterpene acids: copalic, 3-hydroxy-copalic, 3-acetoxy-copalic, hardwickiic, kolavic-15-metyl ester, and kaurenoic, isolated from the oleoresins of Copaifera spp. The diterpenes did not show cytotoxicity in normal cell lines, nor did they show significant changes in viability of tumoral line cells. The 3-hydroxy-copalic was able to inhibit the enzyme tyrosinase (64% ± 1.5%) at 250 µM. The kolavic-15-metyl ester at 200 µM showed high inhibitory effect on lipoxygenase (89.5% ± 1.2%). Among the diterpenes tested, only kaurenoic and copalic acids showed significant hemolytic activities with 61.7% and 38.4% at 100 µM, respectively. In addition, it was observed that only the copalic acid (98.5% ± 1.3%) and hardwickiic acid (92.7% ± 4.9%) at 100 mM inhibited nitric oxide production in macrophages activated by lipopolysaccharide. In this assay, the diterpenes did not inhibit tumor necrosis factor-α production. The acids inhibited the production of IL-6, 3-acetoxy-copalic (23.8% ± 8.2%), kaurenoic (11.2% ± 5.7%), kolavic-15-methyl ester (17.3% ± 4.2%), and copalic (4.2% ± 1.8%), respectively, at 25 µM. The kaurenoic, 3-acetoxy-copalic and copalic acids increased IL-10 production. This study may provide a basis for future studies on the therapeutic role of diterpenic acids in treating acute injuries such as inflammation or skin disorders.
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