ArticleEnvironmental health perspectives2015
Identification and Prioritization of Relationships between Environmental Stressors and Adverse Human Health Impacts.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Design and methodology challenges of environment-wide association studies: A systematic review.Environmental research · 2020Pooled it
- A systematic review of data mining and machine learning for air pollution epidemiology.BMC public health · 2017Pooled it
- Exposure forecasting - ExpoCast - for data-poor chemicals in commerce and the environment.Journal of exposure science & environmental epidemiology · 2022Review
- Application of Pattern Mining Methods to Assess Exposures to Multiple Airborne Chemical Agents in Two Large Occupational Exposure Databases from France.International journal of environmental research and public health · 2022Article
- Data Mining Approaches for Assessing Chemical Coexposures Using Consumer Product Purchase Data.Risk analysis : an official publication of the Society for Risk Analysis · 2021Article
- A New View of the Things We Use: Using Purchasing Data to Predict Common Mixture Exposures.Environmental health perspectives · 2021Article
- Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium.Metallomics : integrated biometal science · 2020Article
- High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity.Environment international · 2020Article
- New Approach Methodologies for Exposure Science.Current opinion in toxicology · 2019Article
- Detection and analysis of endogenous polar volatile organic compounds (PVOCs) in urine for human exposome research.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2019Article
- Cumulative Risk and Impact Modeling on Environmental Chemical and Social Stressors.Current environmental health reports · 2018Review
- Associations between socio-demographic characteristics and chemical concentrations contributing to cumulative exposures in the United States.Journal of exposure science & environmental epidemiology · 2017Article
- A Method for Identifying Prevalent Chemical Combinations in the U.S. Population.Environmental health perspectives · 2017Article
- The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.Environmental health perspectives · 2016Review
- A database of human exposomes and phenomes from the US National Health and Nutrition Examination Survey.Scientific data · 2016Article
- Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources.Current environmental health reports · 2016Review
- Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities.Environmental health perspectives · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are > 80,000 chemicals in commerce with few data available describing their impacts on human health. Biomonitoring surveys, such as the NHANES (National Health and Nutrition Examination Survey), offer one route to identifying possible relationships between environmental chemicals and health impacts, but sparse data and the complexity of traditional models make it difficult to leverage effectively.
objectiveWe describe a workflow to efficiently and comprehensively evaluate and prioritize chemical-health impact relationships from the NHANES biomonitoring survey studies.
methodsUsing a frequent itemset mining (FIM) approach, we identified relationships between chemicals and health biomarkers and diseases.
resultsThe FIM method identified 7,848 relationships between 219 chemicals and 93 health outcomes/biomarkers. Two case studies used to evaluate the FIM rankings demonstrate that the FIM approach is able to identify published relationships. Because the relationships are derived from the vast majority of the chemicals monitored by NHANES, the resulting list of associations is appropriate for evaluating results from targeted data mining or identifying novel candidate relationships for more detailed investigation.
conclusionsBecause of the computational efficiency of the FIM method, all chemicals and health effects can be considered in a single analysis. The resulting list provides a comprehensive summary of the chemical/health co-occurrences from NHANES that are higher than expected by chance. This information enables ranking and prioritization on chemicals or health effects of interest for evaluation of published results and design of future studies. CITATION: Bell SM, Edwards SW. 2015. Identification and prioritization of relationships between environmental stressors and adverse human health impacts. Environ Health Perspect 123:1193-1199; http://dx.doi.org/10.1289/ehp.1409138.
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