ArticleBrain structure & function2016
A central mesencephalic reticular formation projection to the supraoculomotor area in macaque monkeys.
Article in Brain structure & function, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Precerebellar paramedian tract cell groups connections: I. Oculomotor internuclear projections.Brain structure & function · 2025Article
- Neural Control of Vergence and Ocular Accommodation.Annual review of vision science · 2025Review
- Brainstem sources of input to the central mesencephalic reticular formation in the macaque.Experimental brain research · 2023Article
- Superior colliculus projections to target populations in the supraoculomotor area of the macaque monkey.Visual neuroscience · 2021Article
- Neural control of rapid binocular eye movements: Saccade-vergence burst neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Is Primate Lens Accommodation Unilaterally or Bilaterally Controlled?Investigative ophthalmology & visual science · 2020Article
- Response Properties of Cells Within the Rostral Superior Colliculus of Strabismic Monkeys.Investigative ophthalmology & visual science · 2019Article
- Central mesencephalic reticular formation control of the near response: lens accommodation circuits.Journal of neurophysiology · 2019Article
- The Dynamic Oval Pupil.Frontiers in neurology · 2019Review
- An Anatomic Characterization of the Midbrain Near Response Neurons in the Macaque Monkey.Investigative ophthalmology & visual science · 2018Article
- Response of supraoculomotor area neurons during combined saccade-vergence movements.Journal of neurophysiology · 2018Article
- A central mesencephalic reticular formation projection to medial rectus motoneurons supplying singly and multiply innervated extraocular muscle fibers.The Journal of comparative neurology · 2017Article
- Electrical stimulation of superior colliculus affects strabismus angle in monkey models for strabismus.Journal of neurophysiology · 2017Article
- Reticular Formation Connections Underlying Horizontal Gaze: The Central Mesencephalic Reticular Formation (cMRF) as a Conduit for the Collicular Saccade Signal.Frontiers in neuroanatomy · 2017Article
- A central mesencephalic reticular formation projection to the Edinger-Westphal nuclei.Brain structure & function · 2016Article
- Transmitter inputs to different motoneuron subgroups in the oculomotor and trochlear nucleus in monkey.Frontiers in neuroanatomy · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The central mesencephalic reticular formation is physiologically implicated in oculomotor function and anatomically interwoven with many parts of the oculomotor system's premotor circuitry. This study in Macaca fascicularis monkeys investigates the pattern of central mesencephalic reticular formation projections to the area in and around the extraocular motor nuclei, with special emphasis on the supraoculomotor area. It also examines the location of the cells responsible for this projection. Injections of biotinylated dextran amine were stereotaxically placed within the central mesencephalic reticular formation to anterogradely label axons and terminals. These revealed bilateral terminal fields in the supraoculomotor area. In addition, dense terminations were found in both the preganglionic Edinger-Westphal nuclei. The dense terminations just dorsal to the oculomotor nucleus overlap with the location of the C-group medial rectus motoneurons projecting to multiply innervated muscle fibers suggesting they may be targeted. Minor terminal fields were observed bilaterally within the borders of the oculomotor and abducens nuclei. Injections including the supraoculomotor area and oculomotor nucleus retrogradely labeled a tight band of neurons crossing the central third of the central mesencephalic reticular formation at all rostrocaudal levels, indicating a subregion of the nucleus provides this projection. Thus, these experiments reveal that a subregion of the central mesencephalic reticular formation may directly project to motoneurons in the oculomotor and abducens nuclei, as well as to preganglionic neurons controlling the tone of intraocular muscles. This pattern of projections suggests an as yet undetermined role in regulating the near triad.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.