ArticleIranian journal of basic medical sciences2014
In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces.
Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
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- Fabrication of a Polycaprolactone/Chitosan Nanofibrous Scaffold Loaded withBiotech (Basel (Switzerland)) · 2023Article
- Herbal Medicines against Hydatid Disease: A Systematic Review (2000-2021).Life (Basel, Switzerland) · 2022Review
- Cytotoxic and Antileishmanial Effects of Various Extracts ofTurkish journal of pharmaceutical sciences · 2021Article
- Scolicidal effects ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Article
- Evaluation of the acute and sub-acute toxicity of the black caraway seed essential oil in Wistar rats.Toxicology reports · 2019Article
- Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets.PLoS neglected tropical diseases · 2018Article
- Article
- Scolicidal agents for protoscolices ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- Evaluation of the antifungal activities of various extracts fromCurrent medical mycology · 2015Article
- Efficacy ofIranian journal of parasitologyArticle
- Synergistic Effects of Combined Caryophyllene and Albendazole against Invaginated and Evaginated Protoscoleces ofIranian journal of parasitologyArticle
- Medicinal Plants, Herbal Compounds, and Other Natural Products Used againstIranian journal of parasitologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis and liver necrosis. The present study was aimed to evaluate scolicidal effects of various extracts of Nigella sativa seeds against protoscoleces of hydatid cyst in an in vitro model. MATERIALS AND
methodsProtoscoleces were aseptically aspirated from naturally infected livers of sheep and goats. Various concentrations of the different extracts of N. sativa (5 to 50 mg/ml) were used for 5 to 60 min. Viability of protoscoleces was confirmed by 0.1% eosin staining.
resultsThe findings exhibited that methanolic extract at the concentration of 50 mg/ml after 10 min of incubation, and aqueous extract at the concentration of 50 mg/ml after 30 min of incubation can kill 100% of protoscoleces. In addition, all of experiments revealed dose-dependent and also time-dependent scolicidal effect of various extracts of N. sativa on the protoscoleces of hydatid cyst.
conclusionThe results of the present study demonstrated that N. sativa may be a natural source for the production of new scolicidal agent for use in hydatid cyst surgery. However, further studies will be required to evaluate scolicidal effects of N. sativa in the in vivo model.
Indexed as
Identifiers
25859304PMC4387222W2167657686What OpenQuestion holds
Registered trials
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