ArticleIranian journal of basic medical sciences2014
Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage.
Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies.Nutrients · 2017Pooled it
- Combination therapy with bone marrow-derived mesenchymal stem cell transplantation and propolis improves streptozotocin-induced kidney injury in diabetic rats.Avicenna journal of phytomedicine · 2026Article
- Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity.Renal failure · 2024Article
- Anti-inflammatory and anti-angiogenic effects ofJournal of medicine and life · 2024Article
- Comprehensive and updated review on anti-oxidant effects ofIranian journal of basic medical sciences · 2024Review
- Hyperhomocysteinemia exacerbates ischemia-reperfusion injury-induced acute kidney injury by mediating oxidative stress, DNA damage, JNK pathway, and apoptosis.Open life sciences · 2021Article
- Nephroprotective effect of methanol extract ofAfrican health sciences · 2020Article
- Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice.Frontiers in physiology · 2020Article
- A glance at black cumin (Iranian journal of basic medical sciences · 2018Review
- Article
- Nigella Sativa Oil Protects the Rat Ovary from Oxidative Injury Due to Ischemia-Reperfusion.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone.Journal of pharmacopuncture · 2017Review
- Review on the Potential Therapeutic Roles ofJournal of pharmacopuncture · 2017Review
- Protective effect of thymoquinone, the active constituent ofIranian journal of basic medical sciences · 2017Article
- Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced Aging in Mice.Journal of pharmacopuncture · 2017Article
- Black SeedIranian journal of pharmaceutical research : IJPR · 2017Review
- Nigella sativa oil attenuates chronic nephrotoxicity induced by oral sodium nitrite: Effects on tissue fibrosis and apoptosis.Redox report : communications in free radical research · 2016Article
- Doxorubicin-induced renal inflammation in rats: Protective role ofAvicenna journal of phytomedicineArticle
- Renal injury, nephrolithiasis and Nigella sativa: A mini review.Avicenna journal of phytomedicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere are a few previously reported studies about the effect of Nigella sativa oil on renal ischemia-reperfusion injury (IRI). The aim of the present study was to test the hypothesis whether pre- or post-treatment with N. sativa hydroalcoholic extract (NSE) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal IRI. MATERIALS AND
methodsIRI was induced by clamping of bilateral renal arteries for 40 min fallowed by reperfusion for 180 min. NSE was prepared in a Soxhlet extractor and administrated with doses of 150 mg/kg or 300 mg/kg at 1 hr before ischemia induction (P-150 and 300) or at the beginning of reperfusion phase (T-150 and 300), via jugular catheter intravenously. The kidneys were then removed and subjected to biochemical analysis, comet assay or histopathological examination.
resultsThe kidneys of untreated IRI rats had a higher histopathological score (P<0.001), while in P-150, as well as T-150 and T-300 groups tubular lesions significantly decreased (P<0.001). Pre- and post-treatment with NSE also resulted in a significant decrease in malondialdehyde (MDA) level (P<0.001) and DNA damage (P<0.001) that were increased by renal I/R injury. NSE treatment also significantly restore (P<0.01) the decrease in renal thiol content caused by IRI.
conclusionThe present study shows N. sativa extract has marked protective action against renal IRI, which may be partly due to its antioxidant effects.
Indexed as
Identifiers
25859302PMC4387234W1587146247What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.