ReviewFrontiers in human neuroscience2015
The first 1000 days of the autistic brain: a systematic review of diffusion imaging studies.
Review in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Trial
- Parent-mediated early intervention in infants and toddlers at elevated likelihood for autism: a systematic review of randomized controlled trials.Frontiers in psychiatry · 2026Review
- Mapping along-tract commissural and association white matter microstructural differences in autistic children and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- The Possible Role of Postnatal Biphasic Dysregulation of IGF-1 Tone in the Etiology of Idiopathic Autism Spectrum Disorder.International journal of molecular sciences · 2025Review
- Review
- Tract- and gray matter- based spatial statistics show white matter and gray matter microstructural differences in autistic males.Frontiers in neuroscience · 2023Article
- Looking for "fNIRS Signature" in Autism Spectrum: A Systematic Review Starting From Preschoolers.Frontiers in neuroscience · 2022Review
- The Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor.Children (Basel, Switzerland) · 2021Review
- Altered Thalamocortical Connectivity in 6-Week-Old Infants at High Familial Risk for Autism Spectrum Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Aberrant auditory system and its developmental implications for autism.Science China. Life sciences · 2021Review
- A Longitudinal Study of White Matter Development in Relation to Changes in Autism Severity Across Early Childhood.Biological psychiatry · 2021Article
- Autism Spectrum Disorder and Childhood Apraxia of Speech: Early Language-Related Hallmarks across Structural MRI Study.Journal of personalized medicine · 2020Article
- Brain Magnetic Resonance Findings in 117 Children with Autism Spectrum Disorder under 5 Years Old.Brain sciences · 2020Article
- Article
- The development of the social brain in baby siblings of children with autism.Current opinion in psychiatry · 2020Review
- A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children.Journal of neurodevelopmental disorders · 2019Article
- Circuits for social learning: A unified model and application to Autism Spectrum Disorder.Neuroscience and biobehavioral reviews · 2019Review
- Precocious myelination in a mouse model of autism.Translational psychiatry · 2019Article
- Altered lateralization of dorsal language tracts in 6-week-old infants at risk for autism.Developmental science · 2019Article
- Brain Network Organization Correlates with Autistic Features in Preschoolers with Autism Spectrum Disorders and in Their Fathers: Preliminary Data from a DWI Analysis.Journal of clinical medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is overwhelming evidence that autism spectrum disorder (ASD) is related to altered brain connectivity. While these alterations are starting to be well characterized in subjects where the clinical picture is fully expressed, less is known on their earlier developmental course. In the present study we systematically reviewed current knowledge on structural connectivity in ASD infants and toddlers. We searched PubMed and Medline databases for all English language papers, published from year 2000, exploring structural connectivity in populations of infants and toddlers whose mean age was below 30 months. Of the 264 papers extracted, four were found to be eligible and were reviewed. Three of the four selected studies reported higher fractional anisotropy values in subjects with ASD compared to controls within commissural fibers, projections fibers, and association fibers, suggesting brain hyper-connectivity in the earliest phases of the disorder. Similar conclusions emerged from the other diffusion parameters assessed. These findings are reversed to what is generally found in studies exploring older patient groups and suggest a developmental course characterized by a shift toward hypo-connectivity starting at a time between two and four years of age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.