ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Effects of Clonidine on Withdrawal From Long-term Dexmedetomidine in the Pediatric Patient.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05575219 (Protocolized Initiation of Clonidine to Prevent Dexmedetomidine Withdrawal), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protocolized Initiation of Clonidine to Prevent Dexmedetomidine Withdrawal: A Prospective Cohort Study
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment and treatment of the withdrawal syndrome in paediatric intensive care units: Systematic review.Medicine · 2020Pooled it
- Dexmedetomidine Use in Critically Ill Children With Acute Respiratory Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2016Trial
- Tiered Approach to Clonidine Dosing to Prevent Dexmedetomidine Withdrawal in Children: A Prospective Pre and Post Interventional Cohort Study.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Tiny doses, big impact: Optimizing sedation weaning to reduce opioid use in a Level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Guanfacine for the management of the behavioral manifestations of delirium in older hospitalized adults.The mental health clinician · 2025Article
- Evaluation of an Enteral Clonidine Taper following Prolonged Dexmedetomidine Exposure in Critically Ill Children.Journal of pediatric intensive care · 2022Article
- Continuous clonidine infusion: an alternative for children on mechanical ventilation.Revista da Associacao Medica Brasileira (1992) · 2022Article
- Prevention of Withdrawal in Pediatric Patients Receiving Long-term Dexmedetomidine Infusions.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Clonidine for the Treatment of Agitation After Dexmedetomidine Discontinuation in Pediatric Patients: A Retrospective Cohort Study.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Stability evaluation of compounded clonidine hydrochloride oral liquids based on a solid-phase extraction HPLC-UV method.PloS one · 2021Article
- Effects of a Clonidine Taper on Dexmedetomidine Use and Withdrawal in Adult Critically Ill Patients-A Pilot Study.Critical care explorations · 2020Article
- The Impact of a Clonidine Transition Protocol on Dexmedetomidine Withdrawal in Critically Ill Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Evaluating the Transition From Dexmedetomidine to Clonidine for the Prevention of Withdrawal in Critically Ill Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Incidence of Dexmedetomidine Withdrawal in Adult Critically Ill Patients: A Pilot Study.Critical care explorations · 2019Article
- Effectivness of Clonidine in Treating Dexmedetomidine Withdrawal in a Patient with Co-Existing Psychiatric Illness: A Case Report.The American journal of case reports · 2018Article
- Sympathomimetic Toxidromes and Other Pharmacological Causes of Acute Hypertension.Current hypertension reports · 2018Review
- Clonidine for Dexmedetomidine Withdrawal in Pediatric Patients: A Single Center's Experience.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
- Survey of the Current Use of Dexmedetomidine and Management of Withdrawal Symptoms in Critically Ill Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare withdrawal symptoms among pediatric intensive care patients receiving clonidine to those not receiving clonidine while being weaned from long-term dexmedetomidine.
methodsThis retrospective analysis evaluated Withdrawal Assessment Tool-1 (WAT-1) scores and hemodynamic parameters in pediatric patients on dexmedetomidine for 5 days or longer between January 1, 2009, and December 31, 2012. The primary objective was to compare withdrawal symptoms based on the number of elevated WAT-1 scores among patients on clonidine to those not on clonidine, while being weaned from long-term dexmedetomidine. The secondary objective was to describe withdrawal symptoms associated with long-term dexmedetomidine use.
resultsNineteen patients (median age, 1.5 years; interquartile range [IQR], 0.67-3.3) received 20 treatment courses of dexmedetomidine for at least 5 days. Clonidine was received by patients during 12 of the treatment courses. The patients in the clonidine group had an average of 0.8 (range, 0-6) elevated WAT-1 scores 24 hours post wean compared to an average of 3.2 (0-8) elevated WAT-1 scores in the no clonidine group (p = 0.49). There were no significant difierences between prewean and postwean systolic or diastolic blood pressures among the 2 groups. The average heart rate during the postwean period was 112 beats per minute (bpm) (range, 88.5-151.5) in the clonidine group compared to 138.4 bpm (range, 117.8-168.3) in the no clonidine group (p = 0.003). In the clonidine group, the mean change in heart rate postwean compared to prewean was an increase of 3.6 bpm (range, -39.6 to 47.5), compared to a mean increase of 29.9 bpm (range, 5.5-74.7) in the no clonidine group (p = 0.042).
conclusionsThere was no difierence in WAT-1 scores between groups, with the clonidine group displaying a trend towards fewer elevated WAT-1 scores during the 24 hours post dexmedetomidine wean. Patients who received clonidine had significantly lower heart rates than the no clonidine group.
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