ReviewSaudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
OCT: New perspectives in neuro-ophthalmology.
Review in Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Pooled it
- Optic disc drusen: a systematic review : Up-to-date and future perspective.International ophthalmology · 2020Pooled it
- Multimodal Characterization of Radiation-Induced Optic Neuropathy after Proton Radiotherapy.Ophthalmology science · 2026Article
- Retinal peripapillary nerve fiber and retinal ganglion cell layer thickening preceed atrophy in children and teenagers with optic disc drusen.Scientific reports · 2025Observational
- Optical coherence tomography and electroretinography in pituitary macroadenomas: a 12-month analysis by age and tumor type.Frontiers in endocrinology · 2025Observational
- Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma.Journal of clinical medicine · 2024Review
- Application of Optical Coherence Tomography (OCT) to Analyze Membrane Fouling under Intermittent Operation.Membranes · 2023Article
- Retinal nerve fiber layer and ganglion cell complex thickness analysis in patients having relative afferent pupillary defect.Indian journal of ophthalmology · 2022Article
- Photoacoustic imaging for microcirculation.Microcirculation (New York, N.Y. : 1994) · 2022Review
- Non-Arteritic Anterior Ischaemic Optic Neuropathy with Progressive Macular Ganglion Cell Atrophy due to COVID-19.Neuro-ophthalmology (Aeolus Press) · 2022Article
- Sellar masses: diagnosis and treatment.Frontiers in ophthalmology · 2022Review
- Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients.International journal of ophthalmology · 2022Article
- Article
- Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury.PLoS genetics · 2021Article
- Role of spectral domain optical coherence tomography in the diagnosis and prognosis of papilledema.Indian journal of ophthalmology · 2021Article
- Segmented retinal analysis in pituitary adenoma with chiasmal compression: A prospective comparative study.Indian journal of ophthalmology · 2021Article
- Micron-scale human enamel layer characterization after orthodontic bracket debonding by intensity-based layer segmentation in optical coherence tomography images.Scientific reports · 2021Article
- Correlations between visual morphological, electrophysiological, and acuity changes in chronic non-arteritic ischemic optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Management of the regression of papilledema with regional axon loss in idiopathic intracranial hypertension patients.International ophthalmology · 2021Article
- OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical coherence tomography (OCT) has become essential to evaluate axonal/neuronal integrity, to assess disease progression in the afferent visual pathway and to predict visual recovery after surgery in compressive optic neuropathies. Besides that OCT testing is considered a powerful biomarker of neurodegeneration and a promising outcome measure for neuroprotective trials in multiple sclerosis (MS). Currently, spectral-domain OCT (SD-OCT) technology allows quantification of retinal individual layers. The Ganglion Cell layer (GCL) investigation has become one of the most useful tools from a neuro-ophthalmic perspective. It has a high correlation with perimetry, is predictive of future progression and is a highly sensitive, specific of several neuro-ophthalmic pathologies. Moreover the superior correlation with clinical measures compared to peripapillary retinal nerve fiber layer (pRNFL) suggests that GCL analysis might be a better approach to examine MS neurodegeneration. In disorders with optic disk edema, such as ischemic optic neuropathy, papillitis and papilledema, reduction in RNFL thickness caused by axonal atrophy is difficult to distinguish from a swelling resolution. In this setting, and in buried optic nerve head drusen (ONHD), GCL analysis may provide more accurate information than RNFL analysis and it might be an early structural indicator of irreversible neuronal loss. Enhanced depth imaging OCT (EDI-OCT) provides in vivo detail of ONHD, allowing to evaluate and quantify the drusen dimensions. OCT is improving our knowledge in hereditary optic neuropathies. Furthermore, there is growing evidence about the role of OCT as an adjunctive biomarker of disorders such as Alzheimer and Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.