ArticleJournal of international oral health : JIOH2015
Presence of Candida albicans in Root Canals of Teeth with Apical Periodontitis and Evaluation of their Possible Role in Failure of Endodontic Treatment.
Article in Journal of international oral health : JIOH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Article
- Synergistic Antifungal Effects of Honokiol and Fluconazole Against Oral Candida: Implications for Managing Drug-Resistant Infections.Clinical and experimental dental research · 2026Article
- Pulpitis as a microbial disease: single-cell insights into host responses and diagnostic biomarkers for vital pulp therapy.Journal of oral microbiology · 2026Review
- Comparative evaluation of antimicrobial-corticosteroid mixture and intracanal cryotherapy on post-instrumentation pain and microbial reduction: A randomized clinical trial.Journal of clinical and experimental dentistry · 2025Review
- Anticandidal Activity of Capsaicin and Its Effect on Ergosterol Biosynthesis and Membrane Integrity ofInternational journal of molecular sciences · 2023Article
- Assessing Efficacy of Clinical Disinfectants for Pathogenic Fungi by Single-Cell Raman Microspectroscopy.Frontiers in cellular and infection microbiology · 2022Article
- Cross-kingdom interaction betweenFrontiers in microbiology · 2022Review
- Carbon Nanotubes for Improved Performances of Endodontic Sealer.Materials (Basel, Switzerland) · 2021Article
- Bacteria Residing at Root Canals Can Induce Cell Proliferation and Alter the Mechanical Properties of Gingival and Cancer Cells.International journal of molecular sciences · 2020Article
- Influence of microbiology on endodontic failure. Literature review.Medicina oral, patologia oral y cirugia bucal · 2019Review
- Design, Evaluation And Antimicrobial Activity Of Egyptian Propolis-Loaded Nanoparticles: Intrinsic Role As A Novel And Naturally Based Root Canal Nanosealer.International journal of nanomedicine · 2019Article
- Antibacterial and antifungal activity of endodontic intracanal medications.Clujul medical (1957) · 2017Article
- Can oral infection be a risk factor for Alzheimer's disease?Journal of oral microbiology · 2015Article
- Clinical Approach of High Technology Techniques for Control and Elimination of Endodontic Microbiota.Journal of lasers in medical sciences · 2015Review
- Antimicrobial efficacy of 2.5% sodium hypochlorite, 2% chlorhexidine, and ozonated water as irrigants in mesiobuccal root canals with severe curvature of mandibular molars.European journal of dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCandidal organisms are commensals of the oral cavity and their opportunistic infection depends on the interplay of local and systemic factors. Endodontic treatment failure has been associated with the persistence of microbial flora following therapy in the root canal system, and this includes fungi like Candida, which are resistant to conventional root canal irrigants. MATERIALS AND
methodsA total of 20 mandibular molars were included in the study of which 15 were primary randomized controlled trial cases, whereas 5 were retreatment cases. The patient's saliva, as well as the root canal flora, were examined for the presence of Candida organisms and further confirmed for the presence of Candida albicans.
resultsOf the 20 samples comprising the study group, the saliva culture revealed 11 of them to have a colony forming unit (CFU) >400 and 9 of the 20 canals microbiology showed CFU >400. Among the 15 first-time root canal treatment cases, saliva examination these revealed 8 of them to have CFU >400 and the canal microbiology of these showed 6 of them to have CFU >400. Among the retreatment cases, 3 of the 5 cases showed CFU >400 in both the saliva DN canal culture.
conclusionCandidal contamination of the root canals could be the cause of endodontic treatment failure and thus emphasizes the importance of rubber dam isolation and the use of irrigants with antifungal properties for sufficient duration during treatment.
Indexed as
Identifiers
25859106PMC4377149What OpenQuestion holds
Registered trials
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